TB

In a recent paper, researchers tested the diagnostic capability of a simplified T cell activation markers (TAM)-based TB assay that takes real-time measurements from a millimetre of blood...

In a recent study, researchers discovered that fighting diseases that take root inside our cells, like TB, requires the body's process of removing old and injured cell components...

In a new study, researchers investigated the role of HIFs in the regulation of CD4 T cell responses during infection with Mycobacterium tuberculosis...

In a recent paper, it is hypothesised that the invasion of  MAP at the portal entry in the presence of specific antibodies can affect the course of infection...

In a recent paper, Khan, et al., hypothesized that the MΦ phenotype can enhance anti-TB function following cytokine stimulation, and this stimulation can explain the development of LTBI...

In a recent paper, Gideon and colleagues demonstrate to us how diverse TB granulomas can be, not just between individuals, but within an individual...

In a recent paper, researchers have investigated the role of M1 macrophages in combating TB infection...

Druszczynska, et al., used targeted liquid chromatography-mass spectrometry (LC-MS/MS) to assess the levels of 30 small metabolites in the serum and M. tb antigen-stimulated blood cultures of active TB children...

Researchers provide insights into comorbidity of diabetes mellitus and TB disease using transcriptomics...

In a recent paper, Kaufmann and colleagues set out to investigate the role PD-1 during Mtb infection, additionally providing insight into the role of PD-1 in infectious diseases...

In a recent paper, the authors sought to identify a biomarker profile that can be used to differentiate borderline QFT results, due to TB-infection, from those that are a result…

In a recent study, researchers have demonstrated that mucosal-associated invariant T (MAIT) cells, a form of immune cells, play several complex roles during diseased and healthy conditions. These MAIT cells…

Beites, et al., have investigated the function and role of an Mtb enzyme that has never been studied in detail. They reported that the enzyme is essential for Mtb's breakdown…

Researchers have made use of flow cytometry to monitor frequencies, phenotype and function of stimulated neutrophils from HIV-negative TB patients...

Researchers from the University of Maryland and the US National Institutes of Health have discovered a novel pathway of host cell manipulation and innate immune evasion by Mtb. They have…

HLA-DR is a molecule typically expressed by antigen-presenting cells and is associated with antigen presentation. Interestingly HLA-DR is also expressed on T cells and has been associated with T cell…

Darrah et al., showed that BCG-IV resulted in superior T cell and antigen-presenting cell recruitment to the lung compared to other vaccination strategies. In addition to T cell and innate immunity, BCG-IV also induced…

Research led by Dr Flynn aimed to determine if CD4 T cells are necessary for protection against reinfection. To test this hypothesis, CD4 T cells were depleted in infected and…

Can we determine host immune responses associated with resolving (sterile) and permissive (M.tb growth and eventual dissemination) granulomas? This summary highlights recent findings that suggest immune signatures associated with M.b…

We highlight a recently published study by Thacker et al., 2020, which utilised the lung-on-a-chip to understand the role of surfactants during the early stages of Mycobacterium tuberculosis (M.tb) growth.…

Researchers sought to identify mechanisms that can account for the increased susceptibility to tuberculosis disease among individuals with diabetes and intermediate hyperglycemia. They demonstrated that patients with intermediate levels of…

Researchers from India and United Kingdom utilised human samples to demonstrates that NIX plays a central role in mitophagy mediated immune and metabolic reprogramming of peripheral immune cells during chronic…

We report findings from a recently published article “A rapid triage test for active pulmonary tuberculosis in adult patients with persistent cough”(Ahmed et al., 2019).Ahmed et al., “hypothesized that a blood protein-based...

To determine if BCG affects early kinetics of M.tb infection and lymphocyte recruitment, Delahaye et al., compared immune responses between naive- and BCG-vaccinated mice infected with M.tb. They showed that…

Dang et al., utilised the human leprosy model to showcase the ability of IL-26 to provide protection against intracellular bacteria. This research opens up the possibility for Th17 cells to…

Ahmed et al., assessed changes in phenotypic markers on MTB-specific CD4+ T cells in peripheral blood mononuclear cells (PBMC) of subjects with active TB from the start to the end…

Lu et al., demonstrate that resistors possess a distinct adaptive immune phenotype illustrated by detection of mature Ab responses and CD40L expressing (IFN-𝛾 -ve) T cells reactive to...

Successful use of PD-1 blockade for cancer immunotherapy, has brought up the question as to whether this same therapy could be successful against infectious diseases such as tuberculosis (TB) and…

22nd November 2018 90% of people exposed to  Mycobacterium tuberculosis (M.tb) clear infection or contain the infection (termed as latency), however there is a percentage that progress to active disease.

25th September, 2018 CD4 T cells, particularly those that express IFN-γ have been shown to be essential for control of Mycobacterium tuberculosis infection in both animal models and humans. However,…

5th September 2018 A recent Analysis by Behr et al., “Revisiting the timetable of tuberculosis”, highlights the need for improved understanding of the timeline of TB progression and its implications…

26th June 2018 Early immune responses to pathogens in the lungs play a role in the clearance or establishment of an infection. Our understanding of immunity in the human lung…

15th May 2018 Murine models of Mycobacterium tuberculosis (M.tb) have been instrumental in demonstrating the importance of CD4 T cells in the control of M.tb infection.

9th April 2018 Paratuberculosis or Johne’s disease (JD) is a debilitating chronic granulomatous enteritis affecting ruminants ...

23rd March 2018 Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is a significant problem, annually causing 1.7 million deaths worldwide. Although a significant proportion of the world population is estimated....

19th March 2018 There is limited knowledge about the about the immunoregulatory effect of  Vitamin B5, pantothenic acid, on the innate and adaptive immunity. Unlike Vitamin B5,  vitamins A, C…

26th February 2018 Srabanti Rakshit, PhD candidate from the Indian Institute of Science, presented her work which aimed to determine unique T cell features that can distinguish LTBI, PTB and…

23rd February 2018 Dr Maziar Divangahi highlighted one of his research groups recent publications (Kauffman et al.,) which aimed to determine if BCG vaccination can induce “long term” immunity against…

29th December, 2017 CD4 T cells, particularly those capable of producing IFN-γ have been shown to play an essential role in immunity...

14th August, 2017Tuberculosis still remains a public health concern especially in developing countries. Although much is known about immune response to M. tuberculosis...

19th June, 2017 Mycobacterium tuberculosis (Mtb) is a bacterium responsible for Tuberculosis disease. Mtb infection results in months of antibiotic treatment...

Tuberculosis is one of the most dangerous infectious diseases with high morbidity and mortality especially in southern Africa. In this region, TB-HIV...

29th March, 2017B cells are not only important for producing antibodies but they also aid the T cell arm of the immune response by antigen presentation.

10th March, 2017 Tuberculosis is caused by a bacterium known as Mycobacterium tuberculosis (M.tb). The presence of drug-resistant strains of the bacteria highlights the fact that the bacteria can easily…

24th February, 2017The focus of studies on the immune response towards tuberculosis (TB) has mostly been on cellular immunity. However, researchers from the Ragon Institute of MGH, MIT and Harvard...

25th January, 2017 In this study, researchers used SIV-infected macaques to gain insight into the immune response towards HIV/TB co-infection.

25th November, 2016Researchers from John Hopkins University may have found a novel target for tuberculosis (TB) therapy. The team, led by Gyanu Lamichhane...

11th November, 2016Active tuberculosis (TB) infection may result in the Mycobacterium tuberculosis bacteria entering the lung, leading to the development of granulomas

21st September, 2016Tuberculosis (TB) in children is a major health problem as it still has high morbidity and mortality. Every year, approximately 1 million children develop TB disease

16th September, 2016The formation of lung granuloma is the pathological hallmark of pulmonary Tuberculosis disease resulting from the direct struggle between the immune system and Mycobacterium tuberculosis.

Nov 17th, 2015 Multi-drug resistant forms of Mycobacterium tuberculosis (M.tb) hamper global efforts to control the spread of TB, a threat to public health

A new phase lll trial called Stand (Shortening Treatments by Advancing Novel Drugs)...

Results from a much anticipated community-based study into the effectiveness of Isonniazid...