microbiome

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Lupus and the microbiome – the flare

In a recent study, researchers have described the link between the growth of a specific gut bacterium, Ruminococcus (blautia) gnavus, to recurrent episodes of systemic lupus erythematosus (SLE), an autoimmune…

StefanJuly 1, 2023

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Your gut microbiome and white blood cells

In a recent study, researchers have investigated the role of intestinal bacteria composition in enhancing the recovery of the neutrophil population in the blood of mice following chemotherapy and/or stem…

StefanDecember 9, 2022

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Cancer, collagen the microbiome and immunity – a link!

In a recent study, researchers have described how cancer cells can produce small amounts of collagen that form a unique matrix which effects the tumour microbiome, protecting it from the…

StefanJuly 27, 2022

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Enhancing the immune response: skin bacteria and the smallpox vaccination

A recent paper by Shmeleva, et al., the researchers have shown that vaccination for smallpox leads to an increase in skin bacteria which may enhance the immune response...

StefanMay 5, 2022

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Atopic dermatitis and the skin microbiome

In this recent review, Koh, et al., has provided insights into the development and treatment of atopic dermatitis. This paper provides more background and new therapeutic developments for this common…

StefanApril 25, 2022

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More than a gut feeling: The implication of gut microbiota in the pathology of Alzheimer’s Disease

A recent study by Verhaar et al, investigated associations among patients with Alzheimer's' disease pathology and their gut microbiota. This study demonstrates that the gut microbiome composition is linked to…

ChelekaMarch 10, 2022

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Toothpaste – a trigger for gut inflammation

A recent study using murine models has reported that an antimicrobial found in toothpaste, triclosan (TCS), in addition to other toys and products, can lead to or trigger gut inflammation.…

ChelekaJanuary 11, 2022

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Microbial fitness and IgA – a balancing act for the intestinal flora

Researchers have recently shown in a murine model that IgA antibodies regulate and modulate, at several levels, the activity of non-pathogenic bacteria...

ChelekaOctober 24, 2021

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Gut Inflammation Linked to a Debilitating Skin Condition

In their recent Frontiers in Immunology article, Yegorov et al., report that psoriasis patients have elevated levels of IL-1α, a cytokine central to the control of inflammation. In addition, the…

ChelekaNovember 24, 2020

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Immuno-Algeria: Microbial dysfunction & allergy

We highlight a lecture by Yasmine Belkaid on "The control of immunity and allergy by Microbiota." She described how data from skin microbiome sequencing in association with immune signatures...

ChelekaAugust 28, 2020

Microbial dysbiosis in HIV is characterized by decreased abundances of Bacteroides, Lactobacillus and beneficial clostridia with increased abundances of Prevotella and pathogenic Proteobacteria, increasing T-cell and DC activation. Loss of secretory IgA may help to explain the outgrowth of pathogenic bacteria. Increased neutrophil and macrophage accumulation in the lamina propria, bacterial activity in the mucosa, and other mechanisms destabilize the mucosa and GI epithelium, leading to MT and further accumulation of inflammatory microbial products and cytokines in circulation. Together, these mechanisms perpetuate an inflammatory cycle that leads to chronic immune activation in ART-treated HIV-infected individuals. ART, antiretroviral therapy; DC, dendritic cell; GI, gastrointestinal; LPS, lipopolysaccharide; MT, microbial translocation. Source: Lyle-Mckinnon et al., 2015.

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Does dysbiosis of the GIT microbiome enhance the neutrophils survival and chronic inflammation in HIV+ individuals?

Microbial dysbiosis in the gut of HIV infected patients, could trigger TLR signalling in neutrophils, increase neutrophil survival and contribute to inflammation and mucosal damage.

ChelekaJune 7, 2019

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Commensal bacteria leverage IgA during colonisation

7th May 2018 Immunoglobulin A (IgA) is the main antibody found in the gut. Studies about effects of IgA are largely in the context of infection or inflammatory disorders. These…

ChelekaMay 7, 2018

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Serum IgA induced by commensal microbes protects against sepsis

6th April 2018 Classical understanding of antibody functions state that IgG and IgA antibodies confer protective systemic and mucosal immunity, respectively.

ChelekaApril 6, 2018

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PD-1-based immunotherapy affected by gut microbiome

24th November, 2017Gut microbiome dysfunction has been linked to several conditions. Researchers have now shown link between resistance to immune checkpoint inhibitors (ICI) which target...

Thandeka MoyoNovember 24, 2017

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Probiotics induce double-positive intraepithelial lymphocytes

9th October, 2017Oral tolerance is important in ensuring that the body does not mount an immune response against everyday foods we ingest. CD4+CD8αα+ double-positive intraepithelial lymphocytes (DP IELs)...

Thandeka MoyoOctober 9, 2017

Cervical spine MRI showing multiple sclerosis

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Gut bacteria induce pro-inflammatory response in MS

15th September, 2017Multiple Sclerosis (MS) is a condition which affects the central nervous system. Researchers from Stanford University School of Medicine have now found a link...

Thandeka MoyoSeptember 15, 2017

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Interaction between microbiome and urogenital schistosomiasis

21st August, 2017The commensal bacteria in the human body has been known to influence the prognosis and development of many diseases and conditions.

Thandeka MoyoAugust 21, 2017

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Cerebral cavernous malformations enhanced by microbiome

7th August, 2017During the last decade, the gut microbiome configuration has been linked to a large range of diseases from obesity, explained through its ability to regulate...

Thandeka MoyoAugust 7, 2017

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Microorganisms in the eye protect against infection

19th July, 2017Commensal bacteria are resident in various parts of the body and are beneficial to human health.

Thandeka MoyoJuly 19, 2017

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Vaginal Microbiome Affects HIV Prevention

23rd June, 2017 Tenofovir is used as a pre-exposure drug for HIV prevention in high risk individuals. While pre-exposure drugs have proven to be highly effective for men, studies on…

Maxwell ChanJune 23, 2017

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Microbiota in T cell survival

Commensal microbiota found in humans has been found to impact various autoimmune diseases by a link to T cell development. The mechanisms behind this were not well understood. Researchers at…

Thandeka MoyoMay 29, 2017

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Changes in gut microbiome in Inflammatory Bowel Disease

17th February, 2017Inflammatory bowel disease (IBD) is a condition characterized by chronic inflammation of the digestive tract...

Thandeka MoyoFebruary 17, 2017

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Rapid evolution of the infant microbiome after birth

27th January, 2017Researchers from the Baylor College of Medicine investigated how the infant microbiome developed from birth into...

Thandeka MoyoJanuary 27, 2017

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Different gut microbes present depending on diet

11th January, 2017 When changing from one diet to another, one might not see immediate effects and the reason for this may lie with the type of gut microbiota...

Thandeka MoyoJanuary 11, 2017

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Gut microbiota influences pathogenesis of Parkinson’s disease

5th December, 2016Researchers have shown that there is a link between the gut microbiome and development of Parkinsons disease (PD). Less than 10% of PD cases...

Thandeka MoyoDecember 6, 2016

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The microbiome has anti-tumor effects

14th November, 2016The microbiome does not only have a role in maintaining a healthy gut environment but has been found in a recent study to also have anti-cancer effects. The…

Thandeka MoyoNovember 15, 2016

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HIV uniquely impacts on gut microbial metabolism

June 9th, 2016 In a study published in the most recent edition of Nature, scientists studied the effects of HIV on the metabolism of gut bacteria......

ShaanJune 9, 2016

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Immune Ontogeny and the microbiome

Intra-dermal vaccination is largely dependent on efficient antigen delivery to the draining lymph nodes according to a paper published in the Journal of Dermatological Science......

Clive GrayMay 17, 2016

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The microbes within us – the microbiological niche of the lungs

August 25, 2015 It is fast becoming evident that our lungs are not a sterile environment, but a micro-environment rich....

Clive GrayAugust 24, 2015

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TLR5-mediated sensing of gut microbiota has a role in response to flu vaccine

Nov 27, 2014 One main question that arises following flu vaccines is why some people still ...

Bonamy HoltakAugust 3, 2015

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A link between the gut microbiome and brain function?

Correlations between the gut microbiome and behavioural conditions, especially autism have made neuroscientists sit up and attempt to understand how gut bacteria may influence the brain. In the most recent…

Bonamy HoltakNovember 17, 2014

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Microbiota helps regulate behaviour in Autism Spectrum Disorders

A number of studies have suggested a role for disturbances in the gut microbial balance ...

Bonamy HoltakJanuary 27, 2014

Lupus and the microbiome – the flare

Your gut microbiome and white blood cells

Cancer, collagen the microbiome and immunity – a link!

Enhancing the immune response: skin bacteria and the smallpox vaccination

Atopic dermatitis and the skin microbiome

More than a gut feeling: The implication of gut microbiota in the pathology of Alzheimer’s Disease

Toothpaste – a trigger for gut inflammation

Microbial fitness and IgA – a balancing act for the intestinal flora

Gut Inflammation Linked to a Debilitating Skin Condition

Immuno-Algeria: Microbial dysfunction & allergy

Does dysbiosis of the GIT microbiome enhance the neutrophils survival and chronic inflammation in HIV+ individuals?

Commensal bacteria leverage IgA during colonisation

Serum IgA induced by commensal microbes protects against sepsis

PD-1-based immunotherapy affected by gut microbiome

Probiotics induce double-positive intraepithelial lymphocytes

Gut bacteria induce pro-inflammatory response in MS

Interaction between microbiome and urogenital schistosomiasis

Cerebral cavernous malformations enhanced by microbiome

Microorganisms in the eye protect against infection

Vaginal Microbiome Affects HIV Prevention

Microbiota in T cell survival

Changes in gut microbiome in Inflammatory Bowel Disease

Rapid evolution of the infant microbiome after birth

Different gut microbes present depending on diet

Gut microbiota influences pathogenesis of Parkinson’s disease

The microbiome has anti-tumor effects

HIV uniquely impacts on gut microbial metabolism

Immune Ontogeny and the microbiome

The microbes within us – the microbiological niche of the lungs

TLR5-mediated sensing of gut microbiota has a role in response to flu vaccine

A link between the gut microbiome and brain function?

Microbiota helps regulate behaviour in Autism Spectrum Disorders

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