malaria

In a recent paper, scientists have discovered a drug resistance mechanism in one of the most dangerous malaria parasites affecting humans...

In a recent study, Schumann, et al., made use of selection-linked integration (SLI) in combination with glmS ribozyme-tagging and established a purification protocol for recombinant PfKelch13 to study the relevance of the abundance, conformational…

In a new study, researchers from the University of Copenhagen and their collaborators, have reported on new insights into acquired adaptive immunity towards malaria following infection and vaccination. An interesting…

In an interesting study, researchers showed that neutrophils contribute significantly to IgG-mediated phagocytosis of blood-stage P. falciparum merozoites and protection against febrile malaria. These findings further elucidate neutrophil antibody-mediated immune…

2 July 2021In a recent clinical trial Jens E. V. Petersen et al may have found a direct mechanism that explains how the sickle-cell hemoglobin (HbAS) trait protects against severe…

P.falciparum is able to modulate the RBC’s membrane stiffness. However, can P.falciparum remodel naïve surrounding RBCs in preparation for invasion while growing inside their host RBC?

Using a systematic search for antibodies that bind broadly to infected erythrocytes, they discovered a new class of Abs generated by insertions of genomic DNA encoding human inhibitory receptors (LAIR1)…

Kariuki et al., demonstrate that individuals with Dantu blood groups express RBC surface proteins that play a role in parasite invasion into the RBC (e.g. CGYPA, GYOC, Band 3) at…

Our second highlight is on talks that focused on understanding malaria parasite transmission, motility and emergence of anti-malarial resistance, as well as the neutrophil activity in malaria friend or foe.…

Our first Immuno-Ethiopia highlight is on talks by Dr Yaw Bediako (PhD), WACCBIP, University of Ghana, about “Immunity to malaria’’ and “Exploring naturally acquired immunity to malaria: Systems Immunology and…

We highlight Dr Yaw Bediako’s (faculty) presentation on “Performing immunological studies in human cohorts - Systems approaches to studying immunity to malaria”.

Induction of robust and in some cases sterilising CD8 T cell immunity against Plasmodium parasite requires Plasmodium sporozoite infection of hepatocytes, known as the malaria liver stage. As a result,…

Lai et al., utilized a murine model of blood stage malaria, where mice were infected with non-lethal Plasmodium yoelii which self resolves. Blood stage malaria causes a systemic ...

27th July 2018 Studies have shown that platelets can bind and kill infected P.falciparum-infected RBCs (iRBC) and platelet depletion ...

17th November, 2017Boyle et al. showed that CD4+ IL-10 producing Pf-specific T cells are of Th1 origin and are associated with reduced parasitemia in children from a high malaria endemic…

16th October, 2017Regulatory T cells (Tregs) are important in the control of the immune response. Anti-cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a checkpoint protein.

4th September, 2017Malaria disease is the result of infection with Plasmodium parasites.  The infection is known to cause some long term adverse effects after the clearance of the parasite including bone…

12th July, 2017Malaria, a vector-borne disease transmitted by mosquitoes, causes flu-like symptoms in infected individuals. If let uncheck, severe symptoms, including seizures...

1st February, 2017Malaria is still a major global health problem affecting large numbers of people mostly in developing countries. Malaria is caused by the Plasmodium parasite...

5th October, 2016Malaria is still a global health concern due to the high morbidity and mortality caused by malaria parasite infection.

26th January, 2016 It has been conundrum for a long time: the link between endemic Burkitt’s lymphoma (eBL) with Plasmodium falciparum malaria infection