Influenza

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What effect does anti PD-1 therapy have on responses to the influenza vaccine?

In a new study, researchers sought to find what effect anti-PD-1 immunotherapies have on the Tfh–B cell axis. To study this, they had a look at the immune responses induced…

StefanSeptember 28, 2022

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Why is flu vaccine induced immunity short-lived?

Davis et al., detected influenza-specific BMPCs and IgG/IgA Abs in volunteers before vaccination. This immunity was due to previous flu vaccination and flu episodes. New seasonal flu vaccination significantly...

ChelekaOctober 12, 2020

Illustration of Human and Murine experimental plan used in Portluri et al.,. (Source: Portluri et al., 2019)

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Sex associated differences to flu vaccination: role of estradiol?

Researchers have observed sex differences influenza vaccine induced immunity, illustrated by faster seroconversion, higher titres of neutralising antibodies and lower hospitalisation rates in females compared to males. Most of these…

ChelekaJuly 19, 2019

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Evolution of flu-vaccine induced B cell responses

Matsude et al., examined “B cell expansion and evolution after vaccination with replication-competent flu vaccine expressing hemagglutinin (HA) H5 glycoprotein”. They studied both plasma (serum) HA-Ab levels as well as…

ChelekaApril 26, 2019

Fig.1 Neutrophil depletion at the end of the first week p.i. (postinfection) enhances survival in aged mice. a Young mouse were administered a neutrophil-depleting monoclonal antibody just prior to inoculation with influenza virus and following infection (as described in Materials and methods) and survival was monitored. Compared to isotype control treated mice, neutrophil-depleted young mice exhibited a significant increase in mortality. *P < 0.05 (Log rank), n = 8–10 per group. b Aged mice were treated per a and survival postinfection was monitored. P value between neutrophil-depleted and control group, P=0.23 (Log-Rank). n=8–10 per group. c Young mice were administered a neutrophil-depleting antibody at day +6 p.i., then intermittently until day +12 p.i. (as described in Materials and methods) and compared to isotype control treated, young infected mice. *P = 0.10 (Log-rank), n = 8–10 per group. d Aged mice were treated according to c and survival was measured postinfection. Aged neutrophil-depleted mice exhibited a significant increased survival as compared to the control group. *P < 0.05 Log-rank, n = 8–10 per group

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Do neutrophils play a role in age-associated increase in flu mortality?

Influenza virus infection causes more mortality in elderly compared to younger people, and one of the main reasons could be aging of the immune system. Aging impairs both innate ...

ChelekaMarch 8, 2019

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Reduced Flu severity due to high fibre diet

17th May 2018 Dietary fibre, particularly products of bacterial fermentation of dietary fibre such as short chain fatty acids (SCFAs) acetate, butyrate and propionate have been shown to have anti-inflammatory…

ChelekaMay 17, 2018

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Influenza-specific lung resident CD8+ T cells maintain diverse TCR profiles

12th February, 2018 CD8+ T cell immunity has been shown to induce cross-protective long lived immunity against different influenza strains.

ChelekaFebruary 12, 2018

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Influenza-specific lung TRM maintain diverse TCR profiles

12th February, 2018 CD8+ T cell immunity has been shown to induce cross-protective long lived immunity against different influenza strains.

ChelekaFebruary 12, 2018

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Asthma increases susceptibility to influenza

3rd April, 2017Researchers, led by Phillip Monk, have found that having asthma increases susceptibility to influenza infections. This phenomenon is due...

Thandeka MoyoApril 3, 2017

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International Remote Conference Highlights: Establishment of memory CD8 cells to influenza

3rd February, 2017The seasonal variability of influenza makes the development of a universal vaccine challenging.

Thandeka MoyoFebruary 3, 2017

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Th1 response leads to effective antibodies against influenza

28th November, 2016Influenza continues to be one of the most concerning viruses as influenza epidemics are still emerging which kill numerous people.

Thandeka MoyoNovember 29, 2016

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TLR5-mediated sensing of gut microbiota has a role in response to flu vaccine

Nov 27, 2014 One main question that arises following flu vaccines is why some people still ...

Bonamy HoltakAugust 3, 2015

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Fruit Bats and Flu

In the past, influenza A virus has been found in fruit bats from Guatemala, Central America. A recent publication in PloS Pathogens, has found similar viruses in bat species…

Bonamy HoltakOctober 31, 2014

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Club cells – identified in Influenza pathogenesis

The immune system's response to most viral infections, including influenza, is to kill and remove the pathogen. Eliminating infected cells rids the body of the infection. This murine study reports…

Bonamy HoltakSeptember 15, 2014

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Characterization of pandemic influenza immune memory after vaccination or infection

Influenza A infection is still a major infectious disease that has appreciable morbidity and mortality as evidenced during the pandemic in 2009. Furthermore antibody responses acquired after natural infection or…

Bonamy HoltakJune 25, 2014

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Results from a novel flu vaccine

Influenza pandemics, such as the H1N1 (swine flu) outbreak in 2009...

Bonamy HoltakApril 17, 2014

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Sex difference noted in response to influenza vaccine

Immune responses to infections and vaccinations have shown females...

Bonamy HoltakJanuary 31, 2014

What effect does anti PD-1 therapy have on responses to the influenza vaccine?

Why is flu vaccine induced immunity short-lived?

Sex associated differences to flu vaccination: role of estradiol?

Evolution of flu-vaccine induced B cell responses

Do neutrophils play a role in age-associated increase in flu mortality?

Reduced Flu severity due to high fibre diet

Influenza-specific lung resident CD8+ T cells maintain diverse TCR profiles

Influenza-specific lung TRM maintain diverse TCR profiles

Asthma increases susceptibility to influenza

International Remote Conference Highlights: Establishment of memory CD8 cells to influenza

Th1 response leads to effective antibodies against influenza

TLR5-mediated sensing of gut microbiota has a role in response to flu vaccine

Fruit Bats and Flu

Club cells – identified in Influenza pathogenesis

Characterization of pandemic influenza immune memory after vaccination or infection

Results from a novel flu vaccine

Sex difference noted in response to influenza vaccine

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