HIV

In a recent study, researchers have made a significant discovery about memory CD4+ T lymphocytes, crucial players in our immune response, in the context of HIV infection...

In a recent scholarly article, researchers have made efforts to elucidate the phenomenon of HIV remission in at least five individuals following a stem cell transplant...

A group of researchers recently published a paper outlining the processes underpinning the capture of HIV-1 viruses in dendritic cells as well as the function that Siglec-1 serves in the…

A recent study from a group of scientists showed that circulating white blood cells called monocytes can be used to detect a persistent reservoir of HIV genes...

In a recent paper, researchers offer fresh understandings into the perplexing mechanism that not only renders HIV extremely elusive but may also be involved in other viral diseases...

In a new study, researchers decided to take a deep dive into TFRs using lymph nodes (LNs) and blood samples of HIV treated and untreated alongside healthy controls to determine…

In a recent paper, researchers investigated the reprogramming of CD8+ T-cells from non-controllers and tested if it could lead to a boost in their antiviral immune response, as a result…

In recent study published in Science, Wymant, et al., reported the presence of a subtype-B variant of HIV-1 with high virulence that has been spreading through the Netherlands during recent…

In a new study, Saluzzo, et al., has reported that the time of starting antiretroviral therapy may influence tumour development. A novel finding as the mechanism underlying the pathophysiology of…

In a new study published in PLOS Pathogens,  researchers have demonstrated how specific features on the surface of HIV-infected cells play a key role in immune system evasion. A significant…

Researchers are investigating alternative strategies to life-long anti-retroviral treatment. An example of such a study, is the antibody (Ab)-mediated protection proof-of-concept trial that tested whether HIV-specific broadly neutralising Ab VRC01…

In a recent study, Lu and colleagues investigated whether reactivation of individual latent cells occurs stochastically in response to LRAs or is a deterministic outcome of an underlying cell state.…

CD4 T cells are well known as the main target for HIV infection, however, their T cell antiviral activity during His infection is not as well known. This year the…

Byrareddy et al. showed that targeting α4β7 using antibodies can prevent HIV viral rebound in the absence of ART in NHPs. Researchers have attempted to replicate Byrareddy et al.,  findings and 3…

CD4 TSCM and TCM cells are considered to play a major role in long-term maintenance of the viral reservoir. However, research of the viral reservoir during acute phase of HIV infection is limited.…

It has been suggested that “inflamm-aging” is due to immune exhaustion which is associated with reduced effector functions and increased expression of inhibitory receptors (IRs). Thus, Belkina et al.,

12th September One of the goals for the HIV research field is to achieve a functional cure for HIV, the elimination of detectable virus without the use of ART. Clinical…

29th August 2018 Several studies with non-human primates (NHPs) have shown that in -vivo administration of an antibody against the integrin can induce persistent Simian immunodeficiency virus (SIV) control, delay…

17th July 2018 A study published by Descours et al.,  in Nature last year, identified CD32a as marker of the CD4 T cell HIV reservoir. This study showed that CD32a+…

13th June 2018 One of the most important question in HIV immunology is how CD8+ T cell contribute to immunity against HIV. Despite the fact the HIV replicates in lymphoid…

1st December, 2017 Boily-Larouche et al., observed that HIV uninfected women had higher frequencies of CD161+CD4+ T cells in the cervix compared to blood...

15th November, 2017Since the discovery of HIV in the 1980s, the virus has spread worldwide, causing the AIDS pandemic. Neutralising antibodies can bind to the virus and prevent it from…

4th October, 2017The development of neutralizing antibodies with breadth and potency against HIV in natural infection is of interest because these neutralizing antibodies may confer protection...

1st September, 2017The in vivo effect of broadly neutralizing antibodies (bnAbs) which are unable to completely neutralize HIV in neutralization assays was poorly understood.

16th August, 2017Cytomegalovirus (CMV) is a chronic viral infection and part of the herpesvirus group, and is associated with a decreased CD4/CD8 ratio and increased...

11th August, 2017Reports have shown that circumcision can reduce HIV infection rates by up to 60%.­ While the mechanism behind its effectiveness is unclear, multiple studies...

14th June, 2017Male circumcision has often been associated with social and religious values; however, recent research has indicated that circumcised males have a lower risk of contracting HIV...

9th June, 2017 Marijuana is widely used to help alleviate the symptoms of a variety of diseases and the side effects of their treatments. With the recent legalization and decriminalization…

2nd June, 2017Pre-Exposure Prophylaxis, or PrEP, is an HIV prevention method for people who are not infected with HIV but are at a high risk of contraction.

When CD4 T cells are infected with HIV, CD8 cytotoxic T cells usually move in to kill the infected cells. However, some CD4...

α4β7 is a gut-homing integrin which is another receptor used by HIV to enter cells. For this reason, it plays a critical role in the pathogenesis of the virus.

Although there are numerous antibodies that target HIV, there is no antibody that has been discovered that is able to...

10th April, 2017Broadly neutralizing antibodies can bind to various HIV strains and prevent entry into cells. For this reason...

31st March, 2017One of the obstacles in curing HIV is that the virus forms reservoirs which cannot be infiltrated by antiretroviral drugs.

22nd March, 2017 As there is no cure for HIV, scientists are investigating ways to control virus replication in infected individuals. A combination...

6th March, 2017 Elite controllers (ECs) are a group of HIV-infected individuals who are able to suppress viral replication and live for many years...

27th February, 2017HIV broadly neutralizing antibodies (bnAbs) have mainly been studied for their use in an HIV vaccine, however these antibodies may be effective in controlling the viral load...

22nd February, 2017HIV transmission through sexual contact takes place primarily through mucosal tissue. Factors such as genital inflammation and...

14th December, 2016Researchers have found that potent, broadly neutralizing antibodies against HIV can be used to make virus-specific chimeric antigen receptor (CAR) T cells that are capable of...

9th December, 2016One of the challenges in HIV vaccine research is developing an immunogen which elicits a strong immune response; strong enough to protect against HIV acquisition.

31st October, 2016HIV superinfection provides a platform for investigation into how the immune system responds to various viral strains and therefore can be used to understand...

28th October, 2016The HIV Envelope (Env) is surrounded by glycans which serve multiple purposes. One of the purposes of glycans is to evade anti-HIV neutralizing antibodies...

26th October, 2016Bacterial Vaginosis (BV) is condition caused by an imbalance between the “good” and “bad” bacteria in the female genital tract (FGT).

24th October, 2016Broadly neutralising antibodies (bnAbs) which target HIV have been found to develop more commonly in children than in adults.

26th September, 2016Dendritic cells play an important role in B-cell activation through the B lymphocyte stimulator (BLyS).

August 1st, 2016 AIDS 2016 was a meeting of the world’s foremost HIV/AIDS researchers in both the social and biological sciences. The conference, whose theme was “Accessing Equity Rights Now,”…

July 27th, 2016 The 21st International AIDS Conference came to a close this past Friday with over 18 000 delegates attending from around the world. The conference included panel discussions,…

July 21st, 2016 Today, July 21 2016, the International AIDS Conference held in Durban, South Africa convened the fourth day of its conference. One session of note was known as…

July 22nd, 2016 In 2014, UNAIDS rolled out the ambitious 90-90-90 target for 2020 in which "90% of all people living with HIV will know their HIV status, 90% of…

July 19th, 2016 Today, July 19 2016, the International AIDS Conference (AIDS 2016) kicked off its second day in Durban, South Africe. Today, a press conference held on the topic…

July 7th, 2016 IInjection drug users (IDUs) are at a greater risk of contracting co-morbidities like HIV, hepatitis, and other blood-contracted diseases. However, it’s possible that the act of injection…