cancer

In a recent paper, researchers described the development of a novel oncolytic virus (OV) called OV-mOX40L for the treatment of pancreatic cancer (Figure 1). The study aimed to combine the…

In a recent study, researchers discovered the presence of NR2F6, a protein that aids tumours in evading the immune system...

In a recent study, researchers have described the evolution of the tumor microenvironment during the progression of gastric cancer...

In a recent study, scientists have provided new insights into B-cell activation and its impact on T-cell potential. By employing advanced molecular techniques researchers investigated various types of B-cells during…

A recent study has provided valuable insights into the underlying mechanisms through which PD-1 maintains the integrity of healthy tissues...

A recent phase 2 study suggests that a new drug called enoblituzumab is safe for men with aggressive prostate cancer and may have a positive effect on cancer throughout the…

Researchers have recently discovered that breast cancer stem cells evade the immune system by coordinating changes in their differentiation and metabolism...

In a recent study, researchers found that outcomes of patients with clear cell renal cell carcinoma may be predicted by the spatial arrangement of immune cells in the tumour microenvironment...

In a recent review, scientists presented numerous key themes in the biology of pancreatic cancer that can act as identifiers for pancreatic cancer therapy, offering substantial insight into the field…

Researchers have highlighted the significance of white blood cells known as neutrophils in eliminating solid tumours...

Recently, scientists discovered a method to make chemotherapy more effective against metastatic breast cancer that has expanded to the bone...

According to a recent study, a man who received a stem cell transplant to address his cancer also showed signs of being HIV-free after the operation...

In a recent study, a group of researchers revealed a protein that is frequently present in lung cancer cells at high levels and that regulates a crucial immunosuppressive pathway that…

In a recent publication, Researcher have found a new role of IFN- γ in supporting Tumor cells to form a Suppressive Tumor Microenvironment (TME) via STAT3...

In a review by Rebecca Adams et al., researchers described the involvement of tumor-associated macrophages (TAM) in failure of CI therapy and potential strategies to target those cells thereby improving…

In a recent study, researchers have developed a new technique that is safer and non-invasive in order to track within brain and breast tumors in living mice...

In a recent paper, researchers were able to show that the development of LRRC15+ myofibroblasts during the process of tumorigenesis is supported by TGFβ signalling in dermatopontin positive (DPT+) universal…

In a new study, Ningbo, et al., has described a novel way of combining two treatments which may be effective in treating treatment-resistant cancers...

In a new study, researchers sought to find out what role CD4 T-cells play when it comes to aiding the tumour-suppressing function of CD8 T-cells, and possibly unpack the exact…

In a new study, researchers described how pre-existing and treatment-induced antibodies against specific antigen targets could reflect the response elicited by anti-tumour drugs and that this response could be predictive…

In a recent paper, researchers sought to deepen our understanding of the role of macrophages and inflammasome activation in the context of an attenuated Salmonella (LVR01) therapy against melanoma...

In a recent paper, Zhang, et al, have developed nanoparticles that can break down the barriers around tumours, reaching cancerous cells, providing a potentially improved and effective treatment for cancers...

In a recent paper, researchers investigated whether humans are capable of undergoing natural cancer immunoediting during the course of cancer progression...

In a recent paper, de Miguel-Perez, et al., have described, validated and tested a blood test that, for the first time, can be used as a liquid biopsy to predict…

In a recent paper, Jaiswal, et al., researchers analysed several human tumour samples as well as T cell populations and tumour types in order to model T cell behaviour during…

In a new study published in Nature Communications, Launonen, et al., have identified and described the mechanism of how ovarian cancer hides from the body's immune system. These findings have…

Avolio, et al., reported that the protein CSDE1 coordinates a complex chain of events that enable senescence in skin cells, significantly slowing down their function without causing death.  The result,…

A study by Su et al has demonstrated that using a Mendelian randomization approach reduce environmental bias on the causal relationship between genetically elevated CRP levels and postmenopausal breast cancer…

In a recent review, Rios-Tamayo, et al., summarize the current basic laboratory testing in multiple myeloma patients and propose a new algorithm to manage and follow up the MP based…

In a recent study by researchers at MIT, Duong, et al., have identified a potential approach to indirectly activate T cells, through the recruitment of a helper immune cells i.e.…

In a recent paper, Horten, et al., have revealed potential causes for T cells exhaustion and how this subset may become non-responsive to immune checkpoint blockade (ICB).

Recently, researchers have identified patterns within tumours that will help with predicting if patients with kidney cancer will respond to immunotherapy.

Researchers have now developed a novel therapy concept for programming the tumour cells to produce a CD47-blocking and immune-activation fusion protein in the hope that this will halt tumour growth...

Through the use of single-cell transcriptome, proteome, and immune cell analysis of the tumour microenvironment (TME), Hicks, et al., were able to show that that combination therapy elicits significant and…

This summary highlights how cells for TIL therapy are generated, considerations for TIL therapy and, the utility of co-administration of TIL therapy with other cancer immunotherapies. The two main protocols…

Professor Soraya Zorro began her lecture with an overview of TILs and TILs therapy. TILs are lymphocyte populations that migrate to and infiltrate the tumour. These lymphocytes recognise specific antigens,…

This article highlights lecture proceeding by Professor Augusto Ochoa which focused on: (i) characteristics, (ii) physiologic functions, (iii)  role in tumour progression and metastasis, (iv) and the potential as therapeutic…

Today, we highlight part 2 of a lecture by Professor Queckenbush at the IUIS-ALACI-ACAAI Immuno-Colombia 2021 course. During her lecture she presented a case study that highlights an exceptional responder…

This summary highlights a lecture presented during the IUIS-ALACI-ACAAI Immuno-Colombia 2021 course-themed "Mechanisms and Approaches to Immunotherapy for Cancer and Chronic Inflammatory Diseases”. Today, we highlight a talk focused on…

Since nothing is known about aged neutrophils in cancer biology and mature neutrophils in the circulation are considered to be heterogenous, Peng et al. examined how metastatic cancers regulate mature…

Although head and neck squamous cell carcinomas (HNSCCs) is the seventh most frequent type of cancer, they both still have no validated biomarkers and lack specific therapies.

To dissect the effect of HIV and HPV on cervical immunity, Mbuya et al. analysed the expression of activation and memory markers on systemic and cervical T cells in relation…

Prof. Ohashi presentation focused on PD-1 blockade, specifically why PD-1 based immunotherapies work for some cancers but not others. She began with an overview of PD-1...

Bockorny et al., demonstrated the utility of pembrolizumab, BL-8040 and chemotherapy against pancreatic cancer which resulted in better outcome (7/22 experiencing partial response) compared to immunotherapy without chemotherapy.

Review describes the underlying potential immunosuppressive effect of gal-3 through his modulation of lymphocytes and macrophages activity, specifically in the prostate and lung cancer. Depending on its location, extracellular or…

Researchers led by Professor Chiharu Nishiyama investigated the gene expression mechanism of PD-L2, a cell-surface molecule that is specifically expressed by DCs and macrophages. In DCs, PD-L2 acts as a…

Scientists from USA have recently reported on the first human phase I clinical trial that tested the safety of using CRISPR edited immune cells in patients with advanced cancer. CRISPR-Cas9…

Functional activity by tumor-associated macrophages (TAMs) contribute to an immunosuppresive micro-environment that inhibits killing of cancerous cells. TAMs have been associated with poor prognosis of cancer patients on immunotherapy. Thus…

Active mutations in KIT tyrosine kinase are found in several cancers, such as acute myeloid leukemia (AML). However, the different locations in the AML cells where KIT induces cancer-specific signaling…

Sánchez-Reyes et al., evaluated the effect of supernatants from cerival cancer derived-cell lines on the phosphorylation of STAT1, NF-kb-p65 and STAT6 and the impact in the secretion profile of cytokines…

Study lead by Prof Ryushin Mizuta, have now discovered exactly how cfDNA is generated. They also talk about the applications of DNase1L3-the enzyme mainly responsible for generating cfDNA-as a novel…

Day 4 of Immuno-Jaipur included talks by Oliver Boyer and Hannes Stockinger. Prof. Olivier Boyer lecture highlighted the origin and perspectives of CAR-T cells for treatment of cancer patients. He briefed…

In addition to talks by Prof Abbas, Day 3 of Immuno-Jaipur included talks on autoimmunity and chronic inflammation. Prof. Bernhard Fleisher gave a talk on autoimmunity in the central nervous…

Early detection of breast cancer offers curable options, however, once metastasized the cancer cannot be cured. With higher rates of breast cancer correlated with western diet consumption...

Cervical cancer, one of the top 5 common cancers in women globally, is often associated with high-risk human papillomavirus (HPV) infections such as oncogenic HPV16 and HPV18.

27August Researchers in South Korea have identified a new method for treating difficult cancers using state-of-the art liposome technology. The purpose of the study was to demonstrate the utility of…

Osteoclasts (OCLs) are multi-nucleated phagocytes of monocytic origin that are responsible for bone resorption. Changes in their bone resorption function are associated with various pathologies such as osteoporosis, chronic inflammation…

Neutrophils have been implicated in tumor pathology, where studies have reported a positive association between high neutrophil levels and tumor progression. Researchers from Europe (Ponzetta et al.,) aimed to determine...

Prior to the study by Professor De Bono and colleagues, no previous study had considered the use of Tisotumab Vedotin, a tissue factor-specific human monoclonal antibody as a treatment option…

Castellano et al., demonstrated the importance of glutamine and glutamate to the survival of these latently-infected macrophages by showing that there was a decrease in the number of cells that survived...

Since the discovery of the Coley toxin in the 19th century, bacterial based immunotherapies have been evaluated for the treatment of cancer. In this regard, Salmonella...

17th August 2018 While improvements in screening procedures and treatments have improved colorectal cancer (CRC) patient outcomes, CRCs still account for 9-10% of all cancers worldwide. While localized cases of…

18th May 2018 Recombinant human interleukin-2 (rhIL-2) is a US Food and Drug Administration approved adjunct therapeutic for treatment of selective types of cancer.

25th April 2018 Immunotherapy has emerged as a promising new cancer treatment modality over the last decade. The components of immune-system are the integral part of tumor microenvironment ..

11th April 2018 In the 19th century, Doctor William Coley noticed that sarcoma patients went into remission after contracting streptococcus infections. He injected them with

26th March 2018 Classical CD4 and CD8 T cell immunity have been the primary focus of understanding T cell immunity during cancer immunotherapy. Unlike classical T cells, unconventional cells are…

15th January, 2018 Several studies have suggested that diabetes and hyperglycemia increases the risk of developing breast cancer and metastatic disease, as.....

8th December, 2017 Cruz-Adalia et al. demonstrated that tpCD4 T cells are capable of priming naïve CD8 T cells, that have a predominantly...

1st November, 2017 Researchers from the Wyss Institute (Hassell et al) developed an in vitro orthotopic lung cancer model utilising the lung on a chip technology, which is able to...

27th October, 2017Antibody-drug conjugates (ADCs) are therapeutics which combine drugs with highly antigen-specific antibodies. Currently, most of these conjugates are joined together...

2nd October, 2017Human papillomaviruses (HPVs) are a major health concern as some types have been to shown to cause cervical cancer. Researchers from the German Cancer Research...

11th September, 2017Several approaches to enhance immunity against tumor cells in cancer patients have been proposed. Therapeutic vaccination has been reported to be one of the most...

21st July, 2017Vitiligo is an autoimmune disease that causes pigment disfiguration in patients. Hair and skin colour is dependent on the production of melanin by melanocytes. With the destruction of…

14th July, 2017Relapsed and refractory acute lymphoblastic leukemia (ALL) is a form of cancer that is responsible for the most childhood cancer deaths and an extremely poor...

28th June, 2017 Human papillomavirus (HPV) is the most common sexually transmitted virus with up to 80% of the sexually active population becoming infected at one point in their lifetime...

26th June, 2017 Using viruses to kill cancer cells is not a new concept. In this Nature Medicine News feature, Shraddha Chakradhar reviews the latest developments in this field and...

8th March, 2017Researchers from the Princess Margaret Cancer Centre, Toronto, have discovered a novel type of innate lymphoid cell (ILC)...

20th February, 2017Nab-paclitaxel is a therapeutic nanoparticle used in the treatment of pancreatic cancer. Researchers from the New York University School of Medicine

8th February, 2017Pembrolizumab is an immunotherapy drug used to treat individuals with advanced melanoma. Researchers from University of California, Los Angeles...

28th December, 2016 The gut microbiota has been shown to influence numerous pathways in the human body. Researchers have now found that the gut microbiota play a beneficial role...

9th November, 2016One of the most effective ways of determining the function of a gene is to perform a gene “knock-out” where the gene is deleted...