Aging

breaking news

How metabolic rewiring influences macrophage function

Recently, a group from the Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, studied how macrophage fumarate hydratase restrains mtRNA-mediated interferon production...

StefanJuly 6, 2023

breaking news

The immune system during old age

In a recent study, scientists have identified a key signalling molecule that, when lacking in certain immune cells, can induce age-related diseases in young mice...

StefanJune 16, 2023

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Skin aging – IL-17 a role player

In a recent study, scientists have discovered that the IL-17 protein plays a crucial role in the aging process of the skin...

StefanJune 14, 2023

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Immunity in centenarians – keys to life?

According to a recent study, centenarians have immune systems that are highly functioning, have effectively adapted to a history of illness, and have unique immune cell types with diverse compositions…

StefanApril 20, 2023

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Immuno-metabolism and cognitive decline

Minhas et al. investigated whether an increase in PGE2 is associated with the development of age-associated maladaptive inflammation and cognitive decline. They focused their research on PGE2 because levels of…

ChelekaJanuary 25, 2021

breaking news

Safety and immunogenicity of the SARS-CoV-2 mRNA-1273 vaccine candidate in older age.

A follow-up article published in NEJM showed that the mRNA vaccine, mRNA-1273, was safe and immunogenic in older vaccine volunteers (56-70 years). The vaccine has also been shown to be…

ChelekaOctober 6, 2020

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Aging & COVID-19

Chen and colleagues reviewed findings on how aging alters immunity to respiratory viral infections with the aim of suggesting potential mechanisms of age-enhanced COVID-19 mortality. They present evidence that indicated…

ChelekaJuly 9, 2020

breaking news

The different clinical characteristics of COVID-19 between children and adults.

Su et al., showed that COVID-19 in children has a mild or asymptomatic clinical process, which is a largely better prognosis than that in adults. However, PCR positivity in stool…

ChelekaApril 12, 2020

Fig.1 Neutrophil depletion at the end of the first week p.i. (postinfection) enhances survival in aged mice. a Young mouse were administered a neutrophil-depleting monoclonal antibody just prior to inoculation with influenza virus and following infection (as described in Materials and methods) and survival was monitored. Compared to isotype control treated mice, neutrophil-depleted young mice exhibited a significant increase in mortality. *P < 0.05 (Log rank), n = 8–10 per group. b Aged mice were treated per a and survival postinfection was monitored. P value between neutrophil-depleted and control group, P=0.23 (Log-Rank). n=8–10 per group. c Young mice were administered a neutrophil-depleting antibody at day +6 p.i., then intermittently until day +12 p.i. (as described in Materials and methods) and compared to isotype control treated, young infected mice. *P = 0.10 (Log-rank), n = 8–10 per group. d Aged mice were treated according to c and survival was measured postinfection. Aged neutrophil-depleted mice exhibited a significant increased survival as compared to the control group. *P < 0.05 Log-rank, n = 8–10 per group

breaking news

Do neutrophils play a role in age-associated increase in flu mortality?

Influenza virus infection causes more mortality in elderly compared to younger people, and one of the main reasons could be aging of the immune system. Aging impairs both innate ...

ChelekaMarch 8, 2019

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Immunosenescence: how does it affect vaccine Ab responses ?

Researchers (Henry et al.,) aimed to determine how “ageing” affects influenza vaccine responses. They focused on flu-vaccine responses, as the highest adult flu...

ChelekaFebruary 20, 2019

breaking news

The role of TNF and aging in susceptibility to infection

14th October, 2016As humans age, their levels of pro-inflammatory cytokines such as tumour necrosis factor (TNF), IL1β and IL6 increase in the serum and tissues.

Thandeka MoyoOctober 14, 2016

breaking news

Why older people may succumb more readily to pneumonia

19th January, 2016 Age is known to be related to the levels of increased inflammatory cytokines in the blood and tissues. General inflammatory conditions

Clive GrayJanuary 19, 2016

How metabolic rewiring influences macrophage function

The immune system during old age

Skin aging – IL-17 a role player

Immunity in centenarians – keys to life?

Immuno-metabolism and cognitive decline

Safety and immunogenicity of the SARS-CoV-2 mRNA-1273 vaccine candidate in older age.

Aging & COVID-19

The different clinical characteristics of COVID-19 between children and adults.

Do neutrophils play a role in age-associated increase in flu mortality?

Immunosenescence: how does it affect vaccine Ab responses ?

The role of TNF and aging in susceptibility to infection

Why older people may succumb more readily to pneumonia

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