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What is your name?
Gurpreet Kaur
What is your current position?
National Post Doctoral Fellow (NPDF-SERB)
Which institute and country do you work in?
Indian Institute of Technology Ropar, Rupnagar, Punjab, India
What is your home country?
India
What are your research interests?
Immunology of Infectious Diseases, Vaccine development, Biotherapeutics
Tell us about yourself and your research interests:
In my most recent position, I am employed as a Post-doctoral fellow at IIT-Ropar (May 2018- present). I am immensely interested in vaccine development towards infectious diseases. Vaccines are the best prophylactic measure, which has eliminated many diseases like polio, measles and small pox. During my PhD, adjuvant effects of IL22 were studied alongwith antigen GroEL as potential vaccine candidate molecules against Salmonella and other microbial infections. My work shows the potential of co- administration of IL22 and GroEL/ fusion construct as recombinant proteins/DNA vaccine constructs in enhancing the immune responses and protective efficacy, circumventing the need of any adjuvant in vaccine development for infectious diseases. In my postdoctoral work, I am working towards development of an improved BCG vaccine i.e., a recombinant BCG vaccine expressing memory enhancing cytokines. Failure to induce a long-lasting protective immunity is the main shortcoming of most of current vaccines. In addition to cognate immune interactions, other distinct signals are required during the induction of sustenance of immune response for instance, signaling through multiple Toll-like receptors (TLRs) and cytokines to shape and skew immune response toward a stable and desired one. Nevertheless, there are tremendous differences in natural infection and vaccine induced immune response. Consequently, it is important to study microbial and immune signals of utmost importance during course of infection and vaccination that are required for development of long-lasting immunological memory and influences the outcome of disease. This may lead to a better understanding for the development of effective vaccines against dreadful diseases, mainly intracellular pathogens.
What are your online profiles?
LinkedIn
Immunology Keywords:
T cells/B cells, Cytokines and Immune Regulation, Immunological memory
