Norberto, a 23-year old white male in his third relapse of a B cell acute lymphoblastic leukemia (B-ALL) has been treated with an infusion of autologous CD19 Chimeric Antigen Receptor (CAR) T cells (CAR-T cells). Ten days later, he felt severe discomfort in the middle of the night, waking up sweaty with high fever, nausea and pain all over his body. He was immediately transferred from the department of hematology to the intensive care unit.
Acknowledgement
This case study was provided by Prof. Olivier Boyer (M.D., Ph.D., Head of the Department of Immunology and Biotherapy) and Dr. Khadija Ait Bih (Pharm.D.) from Rouen University Hospital, France. The authors would like to thank Jean-Baptiste Latouche (Rouen University Hospital), Ibrahim Yakoub-Agha (Lille University Hospital), Renier Brentjens (Memorial Sloan Kettering, New York) and Monica Guzman (Weill Cornell Medicine, New York) for their critical reading of this case study.
