CD27 expression identifies Th17 cells with high stemness properties
Karmaus et al., showed that during chronic autoimmunity Th17 cells are heterogenous, where Th17 cells with enriched stemness properties are CD27+TCF1hi, while IFN-γ expressing Th17 cells with high metabolic activity…
ChelekaOctober 2, 2019
![This illustration depicts a three-dimensional (3D) computer-generated image of a group of aerobic, Gram-negative, Bordetella pertussis bacteria. The artistic recreation was based upon scanning electron microscopic (SEM) imagery. [Source: CDC PHIL: CDC/ Sarah Bailey Cutchin]](https://new.immunopaedia.com/wp-content/uploads/2019/06/250619.jpg)
![Early T cell–dependent PBs form in the absence of single dif- ferentiated CD4+ T cell subsets. (A) Identification of PE+ cells among CD90.22CD11c2F4/802Gr-12 cells (left panel) from PE-enriched spleen and lymph node samples from WT mice immunized with 2W-PE in CFA 11 d earlier. The middle and right panels show gates used to identify PE-specific PBs (B220lowIgG [H+L]high) or GC B cells (B220highCD382GL7+). (B) Numbers of PE-specific total (left panel) and GC B cells (right panel). (C) Gating and (D) numbers of IgM2IgD2 PBs. Data are expressed as the mean value and repre- sentative of two independent experiments (n = 2–6 mice/group). The p values were obtained from a one-way ANOVA and Dunnett posttest that compares all groups with the WT control group. *p , 0.05, ***p , 0.001.](https://new.immunopaedia.com/wp-content/uploads/2018/12/191218.png)
