NIX is essential for systemic metabolic reprogramming of immune cells mediating tuberculosis protection
![]()
Researchers from India and United Kingdom utilised human samples to demonstrates that NIX plays a central role in mitophagy mediated immune and metabolic reprogramming of peripheral immune cells during chronic…
ChelekaOctober 23, 2020
![Timeline of Rapid Covid-19 Genomewide Association Study (GWAS). The main events and milestones of the study are summarized in the plot. Samples from patients in three Italian hospitals (hospital A: Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan; hospital B: Humanitas Clinical and Research Center, IRCCS, Milan; and hospital C: UNIMIB School of Medicine, San Gerardo Hospital, Monza) and four Spanish hospitals (hospital A: Hospital Clínic and IDIBAPS, Barcelona; hospital B: Hospital Universitario Vall d’Hebron, Barcelona; hospital C: Hospital Universitario Ramón y Cajal, Madrid; and hospital D: Donostia University Hospital, San Sebastian) were obtained around the peak of the local epidemics, and ethics applications were quickly obtained by means of fast-track procedures (i.e., every local ethics review board supported studies of coronavirus disease 2019 [Covid-19] studies by providing rapid turn-around times, thus facilitating this fast de novo data generation). All the obtained blood samples were centrally isolated, genotyped, and analyzed within 8 weeks. Control data were obtained from control participants and from historical control data in Italy and Spain. The rapid workflow from patients to target identification shows the usefulness of GWAS, a standardized research tool that often relies on international and interdisciplinary cooperation. One center alone could not have completed this study, not to mention the increase in statistical power that was available because of the contribution of patients from multiple centers. The speed of data production depended heavily on laboratory automation, and the speed of analyses reflects existing analytic pipelines and the support of public so-called imputation servers (here, the Michigan imputation server of the G. Abecasis group). QC denotes quality control.](https://new.immunopaedia.com/wp-content/uploads/2020/06/Screenshot-2020-06-22-at-11.00.53-1024x524.png)
