breaking news – Page 5 – NEW Immunopaedia

breaking news

Can reprogramming CD8 T-cells contribute to a cure for a HIV?

In a recent paper, researchers investigated the reprogramming of CD8+ T-cells from non-controllers and tested if it could lead to a boost in their antiviral immune response, as a result…

Stefan BothaJuly 22, 2022

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An inflammatory pathway linked to autoimmune diseases

In a recent paper, researchers have identified and described a biochemical pathway that is essential for the production, transport, and action of oxidised mtDNA which may trigger inflammation in the…

Stefan BothaJuly 21, 2022

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Developing new tools to combat COVID-19

Hans-Martin, et al., reported the isolation of monoclonal antibodies from TRIANNI mice, which can be used to provide a pair of non-competing human monoclonal antibodies for clinical development...

Stefan BothaJuly 19, 2022

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SARS-CoV-2 omicron variant hardly evade neutralization by S309

In a recent study, researchers described the X-ray crystal structure of a complex of the Omicron RBD with broadly neutralizing sarbecovirus mAb S309...

Stefan BothaJuly 18, 2022

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Hair growth and our immune system

In a recent paper, researchers have identified a potential target for treatment of alopecia, a autoimmune disorder whereby the immune system attacks the hair follicles resulting in hair loss...

Stefan BothaJuly 13, 2022

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SARS-CoV-2 – a weakness?

In a recent paper, researchers have identified and described an epitope capable of neutralising a variety of coronaviruses including SARS-CoV-1, WIV1 and SHC014...

Stefan BothaJuly 11, 2022

breaking news

The immune system and obesity

In a recent paper by Schmidt, et al., researchers have investigated the immunoregulatory effects of type 2 T helper (Th2) cells in an environment characterised by significantly high fat stores…

Stefan BothaJuly 8, 2022

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Adaptations of tissue-resident memory T cells

In a recent paper by Crowl, et al., researchers provide novel insights into CD8+ tissue-resident memory T cells, describing how these cells adapt when present within specific environments, differing from…

Stefan BothaJuly 7, 2022

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Using lipid nanoparticles for cancer treatment

In a recent paper, Zhang, et al, have developed nanoparticles that can break down the barriers around tumours, reaching cancerous cells, providing a potentially improved and effective treatment for cancers...

Stefan BothaJuly 6, 2022

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A vaccine with a dual threat to cancer

In a recent paper, Badrinath and colleagues report of a vaccine designed to target one tumour immune escape mechanism...

Stefan BothaJuly 1, 2022

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Can BCG vaccination reduce mortality and morbidity from COVID-19?

In a recent paper, researchers looked at the affects of BCG vaccination of COVID-19 mortality and morbidity...

Stefan BothaJune 27, 2022

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A potential new vaccine for rabies

In a recent paper, Callaway, et al., identified and described a potential new and improved rabies vaccine design. A groundbreaking effort by researchers...

Stefan BothaJune 24, 2022

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Does cancer immunoediting occur in humans?

In a recent paper, researchers investigated whether humans are capable of undergoing natural cancer immunoediting during the course of cancer progression...

Stefan BothaJune 23, 2022

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What happens to your cilia during SARS-CoV-2 infection?

In a recent paper, Fonseca, et al., sought out to describe the interaction between ORF10 and ZYG11B and determine whether it promotes the spread of SARS-CoV-2...

Stefan BothaJune 22, 2022

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T cell lineage fate is driven by CD4 and CD8 co-receptor gene loci

Shinzawa and colleagues aimed to identify whether the fate of thymocyte lineage is determined by coreceptor gene loci that regulate TCR signal duration, or by coreceptor proteins, which determine TCR…

Stefan BothaJune 19, 2022

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Novel insights: immunotherapy responses in lung cancer

In a recent paper, de Miguel-Perez, et al., have described, validated and tested a blood test that, for the first time, can be used as a liquid biopsy to predict…

Stefan BothaJune 16, 2022

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Comparing four COVID-19 vaccines

In a new study, researchers have investigated the level of induction of immunity from four different types of COVID-19 vaccines. They looked at how T-cells, B-cells, antibody levels change over…

Stefan BothaJune 13, 2022

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Does the timing of granuloma formation affect TB control?

In a recent paper, Gideon and colleagues demonstrate to us how diverse TB granulomas can be, not just between individuals, but within an individual...

Stefan BothaJune 9, 2022

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ATLAS – describing SARS-CoV-2 variant T-cell responses

In a recent paper, Foti, et al., aimed to characterise the T-cell antigen response in response to SARS-CoV-2 variants using the ATLAS screening assay...

Stefan BothaJune 7, 2022

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Human M1 macrophages champion the control of TB disease

In a recent paper, researchers have investigated the role of M1 macrophages in combating TB infection...

Stefan BothaJune 2, 2022

breaking news

Cannabidiol – a potential tool for fighting SARS-CoV-2

In a new study, Fernandes, et al., aimed to determine the function of ORF8 and ORF10 genes and SARS-CoV-2 Membrane (M) protein and there effect on apoptosis...

Stefan BothaMay 30, 2022

breaking news

Improving Chagas disease diagnosis and treatment

Researchers from Sweden have described the variant formation of Trypanosoma cruzi which are capable of evading the immune system and causing disease...

Stefan BothaMay 27, 2022

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Bifonazole – a potential treatment for SARS-CoV-2 infection

In a recent paper by Taha, et al., the researchers identified the imidazole-based antifungal, Bifonazole, and characterised its activity against SARS-CoV-2 using high-throughput screening techniques...

Stefan BothaMay 25, 2022

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Immunodiagnostic of onchocerciasis: do we have the right tool to end the game?

In a recent study, a team from the Centre for Research on Filariasis and other Tropical Diseases (CRFilMT) collected samples of individuals living in a highly endemic focus in Central…

Stefan BothaMay 23, 2022

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Stopping inflammation in its tracks

In this recent paper, researchers were able to show the direction and degree of which the NLRP3 structure/filament expands during inflammation using cryo-electron microscopy...

Stefan BothaMay 18, 2022

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T cells and melanomas – a potential predictive tool

In a recent paper, Jaiswal, et al., researchers analysed several human tumour samples as well as T cell populations and tumour types in order to model T cell behaviour during…

Stefan BothaMay 17, 2022

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COVID-19 mortality and genetic predisposition

In a new paper by Anderson, et al., the researchers established a detailed model which links COVID-19 mortality and age...

Stefan BothaMay 16, 2022

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Novel vaccines induce neutralising antibodies against Epstein-Barr virus in mice

Following the development of two new vaccines for the treatment of Epstein-Barr virus, a recent study by Wei, et al., have evaluated the effectiveness of these vaccines in mouse models...

Stefan BothaMay 11, 2022

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SARS-CoV-2 and partial resistance to remdesivir

A recent study by Stevens, et al., has demonstrated partial resistance of SARS-CoV-2 to the antiviral drug, remdesivir, in vitro.

Stefan BothaMay 10, 2022

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Enhancing the immune response: skin bacteria and the smallpox vaccination

A recent paper by Shmeleva, et al., the researchers have shown that vaccination for smallpox leads to an increase in skin bacteria which may enhance the immune response...

Stefan BothaMay 5, 2022

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Leaky gut in COVID-19 and its impact on Neutrophil Extracellular Trap formation

Saithong, et al., have hypothesized now that severe COVID-19 causes leaky gut and gut translocation of pathogenic cell wall components enhancing the formation of NETs and sepsis severity...

Stefan BothaMay 4, 2022

breaking news

Where is single cell genomics taking the field of Immunology?

In a recent paper, Ginhoux and colleagues shed light and provide insight into the ever-expanding world of singe-cell immunology, highlighting the power of the technology for future use...

Stefan BothaApril 29, 2022

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TB diagnosis in children: metabolite biomarkers

Druszczynska, et al., used targeted liquid chromatography-mass spectrometry (LC-MS/MS) to assess the levels of 30 small metabolites in the serum and M. tb antigen-stimulated blood cultures of active TB children...

Stefan BothaApril 28, 2022

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Atopic dermatitis and the skin microbiome

In this recent review, Koh, et al., has provided insights into the development and treatment of atopic dermatitis. This paper provides more background and new therapeutic developments for this common…

Stefan BothaApril 25, 2022

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Improving treatments for autoimmune diseases

In a recent paper by Yazar, et al., the researchers used a unique immune cell fingerprint in order to accurately identify treatments for certain autoimmune disease...

Stefan BothaApril 20, 2022

breaking news

Developing monoclonal antibodies against SARS-CoV-2

A recent paper by Mishra, et al., aimed to identify and describe the type of antibodies produced against nine SARS-CoV-2 proteins. In this present study, 18 fab-phage clones were identified…

Stefan BothaApril 20, 2022

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TB treatment with diabetes comorbidity: new insights

Researchers provide insights into comorbidity of diabetes mellitus and TB disease using transcriptomics...

ChelekaApril 13, 2022

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SARS-CoV-2 and T-cell escape

A recent paper by Ahmed, et al., aimed to identify and screen the mutations of SARS-CoV-2 involved in CD8+ T-cell escape....

ChelekaApril 13, 2022

breaking news

B cell signalling deficiencies – new insights into treatments

In a recent paper, researchers have identified a key protein which is involved in B cell signalling. Akatsu, et al., identified CD22, a molecule which is key for the B…

ChelekaApril 8, 2022

breaking news

SARS-CoV-2 and mucosal immunity

In the present study, Chan et al., investigated mucosal SARS-CoV-2-specific antibody levels and aimed to describe neutralisation in children and adults infected with SARS-CoV-2...

ChelekaApril 6, 2022

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The role of the PD-1 blockade in Mycobacterium tuberculosis infection

In a recent paper, Kaufmann and colleagues set out to investigate the role PD-1 during Mtb infection, additionally providing insight into the role of PD-1 in infectious diseases...

ChelekaApril 4, 2022

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Sugar and autoimmune diseases: what are the risks?

Hochrein, et al., has reported that a specific glucose transporter (GLUT3) may be implicated in other metabolic functions in addition to its main role of generating energy from glucose...

ChelekaApril 4, 2022

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B-cell immunity against SARS-CoV-2 in unexposed individuals

In a recent paper, Ercanoglu, et al., sought out to provide a detailed analysis of the B cell immunity to SARS-CoV-2 in unexposed individuals, investigating pre-pandemic blood samples from 150…

ChelekaMarch 29, 2022

breaking news

Enhanced production of effective and personalised vaccines for cancer

In a recent paper by Feola, et al., researchers have developed a pipeline for evaluating, prioritising and identifying potential tumour antigens for the production of vaccines against cancers. The pipeline currently being…

Stefan BothaMarch 29, 2022

breaking news

COVID-19: antigen-specific T cell response and immuno-metabolomic signatures

In a new study by Binayke, et al., the researchers investigated the innate and adaptive immune responses during both the late and early stage of SARS-CoV-2 infection. They also wanted…

Stefan BothaMarch 23, 2022

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Biomarkers to identify Mycobacterium tuberculosis-infection: finding the needle in a haystack

In a recent paper, the authors sought to identify a biomarker profile that can be used to differentiate borderline QFT results, due to TB-infection, from those that are a result…

ChelekaMarch 19, 2022

breaking news

T cells and skin disease

Roediger, et al., suggested that the role of T cells, particularly due to their implication in the TH2 phenotype, in Inflammatory skin disease (ISD) could be a therapeutic avenue which…

ChelekaMarch 16, 2022

breaking news

B-cell immunity following SARS-COV-2 mRNA vaccination – 6 months on…

In a recent paper by Markewitz, et al., the researchers aimed to investigate and determine the levels of anti-SARS-CoV-2 antibodies in individuals who have been vaccinated with a mRNA COVID-19…

ChelekaMarch 15, 2022

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A potential mRNA vaccine for SARS-CoV-2 Omicron variant

In a recent study, Wu, et al., aimed to develop a messenger ribonucleic acid (mRNA) vaccine using the SARS-CoV-2 Omicron variant sequence as a target. The aim was to develop…

ChelekaMarch 11, 2022

breaking news

More than a gut feeling: The implication of gut microbiota in the pathology of Alzheimer’s Disease

A recent study by Verhaar et al, investigated associations among patients with Alzheimer's' disease pathology and their gut microbiota. This study demonstrates that the gut microbiome composition is linked to…

ChelekaMarch 10, 2022

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MAIT cells – a new target for future immunotherapies and vaccines

In a recent study, researchers have demonstrated that mucosal-associated invariant T (MAIT) cells, a form of immune cells, play several complex roles during diseased and healthy conditions. These MAIT cells…

ChelekaMarch 7, 2022

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Immune memory in the intestine: new insights into “innate memory”

In a recent paper, Serafinain, et al., have made us of an intestinal infection model to discover that group 3 innate lymphoid cells (cells of the innate immune system) may…

ChelekaMarch 3, 2022

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A new tool fight SARS-CoV-2: an ACE2-blocking antibody

In a new study, Du, et al., have identified a neutralising monoclonal antibody in humans, 87G7, against SARS-CoV-2 which has shown widespread neutralisation and immunisation efficacy against SARS-CoV-2 VOCs...

ChelekaFebruary 28, 2022

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Novel HIV-1 variant found in Netherlands: the implications

In recent study published in Science, Wymant, et al., reported the presence of a subtype-B variant of HIV-1 with high virulence that has been spreading through the Netherlands during recent…

ChelekaFebruary 24, 2022

breaking news

Understanding the immune system and COVID-19: New insights

Researchers today are still trying to understand how the immune system's natural killer (NK) cells identify SARS-CoV-2 infected cells. In a recent paper, Hammer, et al., have reported that NK…

ChelekaFebruary 23, 2022

breaking news

Ovarian cancer and immune evasion

In a new study published in Nature Communications, Launonen, et al., have identified and described the mechanism of how ovarian cancer hides from the body's immune system. These findings have…

ChelekaFebruary 18, 2022

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A new TB vaccine – is it cost-effective and efficient?

In a new study, Harris, et al., investigated the potential health impact and cost-effectiveness of the M72/AS01E vaccine in two high burden TB countries: India and South Africa

ChelekaFebruary 16, 2022

breaking news

More SARS-CoV-2 variants?

A recent paper by Foix, et al., has reported on the potential of existing strains of SARS-CoV-2, and future variants to escape the immune system's cytotoxic T cell response.

ChelekaFebruary 14, 2022

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HIV vaccine progress

In a recent paper, Ziyang, et al., have produced novel insights into and further developed an HIV vaccine through the use of a unique trimer in order to develop Tier-2…

ChelekaFebruary 10, 2022

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A nanoparticle based vaccine for SARS-CoV-2 neutralization and protection

In a recent study, researchers have demonstrated that the SARS-CoV-2 receptor-binding domain (RBD)-based, sortase A-conjugated nanoparticle (RBD-scNP) vaccine induces neutralizing antibodies (NAbs) in non-human primates (NHPs) against all eight variants of SARS-CoV-2.

ChelekaFebruary 7, 2022

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Predicting transplant rejection using proteoforms

In a recent study published in Science, Melani, et al., have reported on a several families of proteins in the body that may be used as a tool to predict…

ChelekaFebruary 6, 2022

breaking news

Epstein-Barr Virus found to trigger Multiple Sclerosis

For decades, researchers have suspected that patients infected with a common virus, Epstein-Barr (EVB), might be more likely to develop multiple sclerosis. Now, a team led by Harvard University researchers…

ChelekaFebruary 2, 2022

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Treatment with interferon-λ confers protection from SARS-CoV-2 variants – Beta and Omicron

In a recent paper, Chong, et al., investigated the effect of IFN-λ on SARS-CoV-2 infection in mice. They found that IFN-λ conferred protection against the SARS-CoV-2 B.1.351 (Beta variant) and…

ChelekaJanuary 31, 2022

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Th17 and Multiple Sclerosis (MS)

In a recent study, Wilson, et al., have described how Th17 cell promote the onset of certain autoimmune diseases such as multiple sclerosis (MS). The researchers have discovered a mechanism…

ChelekaJanuary 28, 2022

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A potential end to peanut allergies?

In a recent paper, results published in The Lancet from a clinical trial has reported that through the administration of peanut oral immunotherapy in children, ages 1-3, who are extremely…

ChelekaJanuary 27, 2022

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Why is SARS-CoV-2 Omicron less severe than Delta?

A new study by Bojkova, et al., reported on the SARS-CoV-2 Omicron variant and why it is less efficient than the Delta variant at inhibiting/blocking the host cellular defense mechanism…

ChelekaJanuary 25, 2022

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A new target for TB treatment with great potential

Beites, et al., have investigated the function and role of an Mtb enzyme that has never been studied in detail. They reported that the enzyme is essential for Mtb's breakdown…

ChelekaJanuary 23, 2022

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Formation of tertiary lymphoid tissue: fighting chronic inflammation

A recent article published in Kidney International highlights novel findings concerning Tertiary lymphoid tissues (TLTs), which are ectopic lymphoid tissues formed due to chronic inflammatory microenvironment which functions as a…

ChelekaJanuary 19, 2022

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Our natural defence to skin cancer – new insights

Avolio, et al., reported that the protein CSDE1 coordinates a complex chain of events that enable senescence in skin cells, significantly slowing down their function without causing death. The result,…

ChelekaJanuary 17, 2022

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Can we use cannabinoids to block SARS-CoV-2 viral entry?

Van Breemen, et al., reported on a pair of cannabinoid acids, cannabigerolic acid (CBGA) and cannabidiolic acid (CBDA), that can bind to the SARS-CoV-2 spike protein, inhibiting/blocking a crucial element…

ChelekaJanuary 13, 2022

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Toothpaste – a trigger for gut inflammation

A recent study using murine models has reported that an antimicrobial found in toothpaste, triclosan (TCS), in addition to other toys and products, can lead to or trigger gut inflammation.…

ChelekaJanuary 11, 2022

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How do immune cells invade tissue?

In a recent discovery that may aid researchers in identifying new targets for cancer treatment, Belyaeva, et al., 2021 have discovered how immune cells protect themselves when they enter and…

ChelekaJanuary 9, 2022

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T-cell response to SARS-CoV-2 Omicron

In a recent observational study, De Marco, et al., investigated mechanisms of how the Omicron variant of SARS-CoV-2 (B.1.1.529) evades cellular immunity. An interesting paper and extremely relevant during these…

ChelekaJanuary 5, 2022

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B cell lymphomas and the role of TET enzymes

A recent study published in Nature Immunology, highlighted how the loss of TET enzymes can lead to B cell lymphoma. The study by Shukla, et al., may provide us with…

ChelekaDecember 31, 2021

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Changes in SARS-CoV-2 Omicron variant spike protein

In a recent preprint, Warwicker investigated the degree to which the D614G mutation in the SARS-CoV-2 receptor-binding domain (RBD) allows access of spike (S) protein trimers to conformations/forms similar to…

ChelekaDecember 31, 2021

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Resistance to key antimalarial drug?

In a recent study, Schumann, et al., made use of selection-linked integration (SLI) in combination with glmS ribozyme-tagging and established a purification protocol for recombinant PfKelch13 to study the relevance of the abundance, conformational…

ChelekaDecember 23, 2021

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COVID-19 and idiopathic pulmonary fibrosis (IPF)

A recent study by Allen, et al., reported a positive genetic correlation between IPF and severe COVID-19 risk. However, it must be noted that some of the IPF-related pathways may…

ChelekaDecember 19, 2021

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Can fat help us combat infection?

In a new study from Nature Communications, Mistry, et al., have reported on how our immune cells use Free Fatty-acid (FFA) transport to fight infection. These insights could help develop…

ChelekaDecember 16, 2021

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Antibody profile in response to SARS-CoV-2 – serological profile and specificity of maternal and neonatal cord blood

In a recent study, researchers investigated the antibody profile of maternal serum and neonatal cord blood antibody responses to SARS-CoV-2 virus exposure in mothers.

ChelekaDecember 13, 2021

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Germline mutations in innate immunity associated with the risk for breast cancer: case of C-reactive protein

A study by Su et al has demonstrated that using a Mendelian randomization approach reduce environmental bias on the causal relationship between genetically elevated CRP levels and postmenopausal breast cancer…

ChelekaDecember 7, 2021

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New Insights into the diagnosis, prognosis and monitoring of Multiple Myeloma: What’s the role of the Heavy/Light Chain Assay?

In a recent review, Rios-Tamayo, et al., summarize the current basic laboratory testing in multiple myeloma patients and propose a new algorithm to manage and follow up the MP based…

ChelekaDecember 2, 2021

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Antiretroviral therapy influences tumour development in patients with HIV

In a new study, Saluzzo, et al., has reported that the time of starting antiretroviral therapy may influence tumour development. A novel finding as the mechanism underlying the pathophysiology of…

ChelekaNovember 29, 2021

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Promotion of protective anti-tumour CD8+ T cell immunity – a new treatment for tumours

In a recent study by researchers at MIT, Duong, et al., have identified a potential approach to indirectly activate T cells, through the recruitment of a helper immune cells i.e.…

ChelekaNovember 25, 2021

breaking news

Alzheimer’s Disease – a potential vaccine?

In a promising new study, researchers from the University of Leicester have developed a new approach to potentially treating and vaccinating against Alzheimer’s disease. An potentially major finding that may…

ChelekaNovember 22, 2021

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Immune system evasion – the HIV-infected cell

In a new study published in PLOS Pathogens, researchers have demonstrated how specific features on the surface of HIV-infected cells play a key role in immune system evasion. A significant…

ChelekaNovember 18, 2021

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Improving existing malaria vaccines – new insights

In a new study, researchers from the University of Copenhagen and their collaborators, have reported on new insights into acquired adaptive immunity towards malaria following infection and vaccination. An interesting…

ChelekaNovember 15, 2021

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Detection of autoantibodies in patients with multisystem inflammatory syndrome in children (MIS-C)

In a recent study, researchers aimed to characterise the presence of autoantibodies against autoantigens associated with known autoimmune diseases...

ChelekaNovember 12, 2021

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Immunotherapy – new insights into how CD8+ T cells become unresponsive to treatment

In a recent paper, Horten, et al., have revealed potential causes for T cells exhaustion and how this subset may become non-responsive to immune checkpoint blockade (ICB).

ChelekaNovember 9, 2021

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Predicting response to immunotherapy in patients with clear cell renal cell carcinoma (ccRCC)

Recently, researchers have identified patterns within tumours that will help with predicting if patients with kidney cancer will respond to immunotherapy.

ChelekaNovember 5, 2021

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Pregnancy and its influence on the immune response to SARS-CoV-2

A recently published focus article has highlighted two interesting studies which investigated the response of pregnant women to natural infections and COVID-19 vaccines. The results are interesting...

ChelekaNovember 2, 2021

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Toxoplasma gondii-Induced Neutrophil Extracellular Traps Activate Neutrophils and promote T cell recruitment

Researchers have now determined the activation status of human neutrophils from patients with acute and chronic infections of T. gondii using flow cytometry.

ChelekaOctober 28, 2021

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Neutrophils as potential early indicators of tuberculosis severity

Researchers have made use of flow cytometry to monitor frequencies, phenotype and function of stimulated neutrophils from HIV-negative TB patients...

ChelekaOctober 26, 2021

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Microbial fitness and IgA – a balancing act for the intestinal flora

Researchers have recently shown in a murine model that IgA antibodies regulate and modulate, at several levels, the activity of non-pathogenic bacteria...

ChelekaOctober 24, 2021

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Malaria Vaccine Breakthrough: Shaking or Stirring the Field?

Being the first and the only approved vaccine of a deadly parasitic disease makes RTS, S a potential part of malaria-control tool kit. This vaccine will help in lowering the…

ChelekaOctober 20, 2021

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A novel immunogene CD47-targeting therapy inhibiting tumour growth

Researchers have now developed a novel therapy concept for programming the tumour cells to produce a CD47-blocking and immune-activation fusion protein in the hope that this will halt tumour growth...

ChelekaOctober 13, 2021

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A novel inhibitor of dengue virus

In a recent study conducted by researchers at the Rega Institute for Medical Research, KU Leuven, have identified and developed an ultrapotent inhibitor of the dengue virus (DENV), which causes…

ChelekaOctober 11, 2021

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Variations in leukocytes – three months following mild COVID-19 infection

Researchers have investigated and described the rate of changes in peripheral blood white cells (WBCs) in individuals who have recovered from SARS-CoV-2 infection...

ChelekaOctober 6, 2021

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Insights into the development of the blood and immune systems in prenatal bone marrow

Researchers from the Wellcome Sanger Institute, Newcastle University and their collaborators have performed a comprehensive analysis of how the blood and immune systems develop in prenatal bone marrow...

ChelekaOctober 4, 2021

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New hope – a potential new treatment for sepsis

Researchers from California have identified molecular biomarkers, pathways and immune cell dynamics associated with sepsis that can be potentially targeted in order to prevent death from and develop new treatments…

ChelekaSeptember 30, 2021

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Identification of D6R and C5aR2 as key molecules with the potential to combat inflammatory diseases

Researchers have identified key molecules within the immune system that have the potential, through their use, to combat inflammation implicated in chronic diseases including COVID-19, cancers and...

ChelekaSeptember 28, 2021

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