breaking news – Page 13 – NEW Immunopaedia

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HIV uniquely impacts on gut microbial metabolism

June 9th, 2016 In a study published in the most recent edition of Nature, scientists studied the effects of HIV on the metabolism of gut bacteria......

ShaanJune 9, 2016

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A potential target for HIV reactivation discovered

June 8th, 2016 Researchers in this study revealed that HSF1, heat shock factor 1, is actively involved with the reactivation of viral HIV strains in latent phases of infection. ......

AbrahamJune 8, 2016

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A promising new treatment for systemic lupus erythematosus (Lupus)

June 7th, 2016 In a recent study from the University of Florida, scientists have discovered a potential treatment for systemic lupus erythematosus (SLE). SLE is an autoimmune disease in which…

AbrahamJune 6, 2016

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Immune Ontogeny and the microbiome

Intra-dermal vaccination is largely dependent on efficient antigen delivery to the draining lymph nodes according to a paper published in the Journal of Dermatological Science......

Clive GrayMay 17, 2016

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Antigen Delivery to the Draining Lymph Nodes is a Key to Intradermal Vaccination Efficacy

Intra-dermal vaccination is largely dependent on efficient antigen delivery to the draining lymph nodes according to a paper published in the Journal of Dermatological Science......

Clive GrayApril 20, 2016

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Trivalent Inactivated Poliovirus Vaccine (IPV) is Non-Superior to Live-Attenuated Oral Poliovirus Vaccine

A recent study on infants in China has successfully demonstrated that primary and booster vaccination with an inactivated poliovirus vaccine (IPV)

Clive GrayMarch 21, 2016

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Intact Ovine Immunoglobulin (EBOTAb) to Treat Ebola Virus Infection?

Researchers have now developed EBOTAb, a pool of intact ovine immunoglobulin G, which has been shown to neutralize Ebola virus (EBOV) in vitro. The primary target was the highly glycosylated…

Clive GrayMarch 21, 2016

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Solving the 50-year-old riddle: the link between Plasmodium falciparum Malaria and Endemic Burkitt’s Lymphoma

26th January, 2016 It has been conundrum for a long time: the link between endemic Burkitt’s lymphoma (eBL) with Plasmodium falciparum malaria infection

Clive GrayJanuary 26, 2016

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Why older people may succumb more readily to pneumonia

19th January, 2016 Age is known to be related to the levels of increased inflammatory cytokines in the blood and tissues. General inflammatory conditions

Clive GrayJanuary 19, 2016

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Does Chlamydia infection result in increased HIV susceptibility?

14th January, 2016 Chlamydia trachomatis is one of the most common sexually transmitted infections (STI) worldwide. In areas of high HIV transmission rates, especially in young females

Clive GrayJanuary 14, 2016

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A new theory to explain autoimmunity: The Altered Glycan Theory of Autoimmunity

4th January, 2016 All cells of the body are made of four classes of molecules: nucleic acids, proteins, lipids and glycans. Of the four, glycans have been least studied

Clive GrayJanuary 4, 2016

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Success of passive HIV immunization?

There has been a plethora of newly discovered HIV neutralizing antibodies (NaB) made over the past 5 years. One such NaB is known as VRC01 and recognizes the CD4 binding…

Clive GrayDecember 24, 2015

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Herd Immunity: immunology meets public health

The impact of immunity to a pathogen at the person level is important for influencing host health as well as how pathogens evolve. The impact of immunity

Clive GrayDecember 22, 2015

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Associations between infant chubbiness and Dengue Haemorrhagic Fever

Dengue fever is caused by the dengue virus, which is principally transmitted by the mosquito A. aegypti. It represents the most prevalent arthropod-borne viral illness in humans, where over 50%

Clive GrayDecember 17, 2015

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Do we need to re-think vaccine strategies to elicit anti-HIV antibodies?

A vaccine that can elicit neutralizing antibodies to HIV, and thus lead to protection from infection, is the holy grail of..

Clive GrayDecember 15, 2015

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SIV infection of Tfh Cells in monkeys

There are multiple subsets of CD4+ T cells: Th1, Th2, Th9, Th17, Th22 to name a few, which are defined by the cytokines they liberate that direct specific immune responses

Clive GrayDecember 11, 2015

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Can wearing silver damage your health?

Many consumer products made of silver nanoparticles (AgNP) could increase susceptibility to infectious pathogens. Systemic uptake of AgNP by macrophages can lead to alterations in their

Clive GrayDecember 8, 2015

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Immune and viral events leading up to acute Infectious Mononucleosis

Dec 4th, 2015 Epstein-Barr virus (EBV) is a human herpesvirus that causes acute infectious mononucleosis and is associated.....

Clive GrayDecember 4, 2015

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World AIDS Day Message

The 1st December 2015 is World AIDS day and another year of progress towards ending the epidemic. There are now 15 million people on life-saving antiretroviral drug treatments

Clive GrayDecember 1, 2015

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Genetically modified commensal bacteria used as a possible HIV vaccine adjunct

Nov 30th, 2015 It is desirable to strive towards an HIV vaccine that elicits mucosal protective immunity to prevent infection of immune cells

Clive GrayNovember 30, 2015

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Prevention of Mother-to-Child HIV transmission in African children in the first year of life

Nov 27th, 2015 A recent study published in The Lancet showed the efficacy and safety of two infant drug regimens....

Clive GrayNovember 27, 2015

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Levels of PD-L1 Expression on target cells helps to establish viral latency

Nov 23rd, 2015 During HIV infection, cytotoxic T lymphocytes (CTL) are able to eliminate virally infected cells at the acute stage of infection.

Clive GrayNovember 23, 2015

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Microbial Gut diversity predicts immune status during HIV-1 infection

Nov 20th, 2015 It is known that HIV-1 infection alters intestinal barrier, causes gut microbiota dysbiosis, and results in systemic inflammation.

Clive GrayNovember 20, 2015

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Stasis of CD8+ T Cells in the brain is a Signature of Cerebral Malaria

Nov 18th, 2015 In the November 12th edition of PloS Pathogens, Shaw et al explored the role of CD8+ T cells in an experimental model of cerebral malaria

Clive GrayNovember 17, 2015

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Diversity of lipid envelopes in Mycobacterium tuberculosis

Nov 17th, 2015 Multi-drug resistant forms of Mycobacterium tuberculosis (M.tb) hamper global efforts to control the spread of TB, a threat to public health

Clive GrayNovember 15, 2015

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A new reservoir of HIV found within peripheral Vδ2 T cells

Nov 13th, 2015 Conventional T cells (which have an alpha:beta T cell receptor) make up the majority of T cells in the peripheral circulation....

Clive GrayNovember 13, 2015

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A new marker denotes exhausted CD8+ T cells during chronic viral infections

Nov 11th, 2015 Persistent viruses induce a state of chronic viral infection that is characterized by inducing a state of T cell........

Clive GrayNovember 11, 2015

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New antibodies that target sugars on the HIV-1 envelope

Nov 9th, 2015 The CD4 binding site on the gp120 portion of the envelope protein of HIV-1 is a vulnerable site, that when targeted could cripple ...

Clive GrayNovember 9, 2015

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Nucleoside reverse-transcriptase inhibitors (NRTIs) as first-line ART in African Children

Oct 9th, 2015 There have been no paediatric trials which have compared nucleoside reverse-transcriptase..

Clive GrayOctober 9, 2015

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What causes the high mutation rates of HIV-1 in the human body?

Oct 7th, 2015 It has been known for a long time that HIV-1 mutates rapidy, and does so to escape the pressure

Clive GrayOctober 7, 2015

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Is Adipose Tissue a viral reservoir?

Oct 5th, 2015 Adipose tissue is made up of adipocytes and the stromal vascular fraction (SVF), which comprises immune cells such as CD4+ T cells....

Clive GrayOctober 4, 2015

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Combination Antibiotic and Pidotimod Therapy against Pneumonia

Sept 15th, 2015 This recent study published in the Journal of Translational Medicine reports for the first time

Clive GraySeptember 14, 2015

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Extracellular vesicles as a vaccine candidate against Staphylococcus aureus infections

Sept 11th, 2015 Staphylococcus aureus (S. aureus) is the major cause of pneumonia, osteomyelitis and sepsis and is also one

Clive GraySeptember 11, 2015

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New Mechanism underlying Rheumatoid Arthritis Pathogenesis

Sept 1st, 2015 Rheumatoid Arthritis (RA) is an autoimmune disorder that affects the joints and while the cause of RA is...

Clive GraySeptember 1, 2015

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Novel model provides quantitative explanation of CD4+ T Cells pathway in vivo

Sept 9th, 2015 Vaccine regimens are often administered in prime-boost combinations. This approach is aimed at eliciting...

Clive GrayAugust 28, 2015

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Pregnancy Induces Activation of Aged Dormant Muscle Progenitor Cells

August 23, 2015 Aging is associated with a decline in cell and tissue regenerative capacity due to changes in growth...

Clive GrayAugust 24, 2015

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The microbes within us – the microbiological niche of the lungs

August 25, 2015 It is fast becoming evident that our lungs are not a sterile environment, but a micro-environment rich....

Clive GrayAugust 24, 2015

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TLR5-mediated sensing of gut microbiota has a role in response to flu vaccine

Nov 27, 2014 One main question that arises following flu vaccines is why some people still ...

Bonamy HoltakAugust 3, 2015

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A link between the gut microbiome and brain function?

Correlations between the gut microbiome and behavioural conditions, especially autism have made neuroscientists sit up and attempt to understand how gut bacteria may influence the brain. In the most recent…

Bonamy HoltakNovember 17, 2014

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Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

Studies suggest that tumor initiation and progression are commonly accompanied by a low grade underlying inflammation...

Bonamy HoltakNovember 12, 2014

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Can environmental non-TB mycobacteria interferes with immunity to TB?

A ubiquitous group of mycobacteria found in the environment are known as non-tuberculous mycobacteria (NTM). These are opportunistic pathogens that can cause disease in people, especially in immunocompromised individuals. Being…

Bonamy HoltakNovember 5, 2014

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Dissecting tumor myeloid compartments to reveal APC critical for T Cell immunity

In the latest edition of Cancer Cell researchers from University of California SF, look closely at intratumoral dendritic cells (DC). It is well understood that antigen-presenting cells (APCs) within tumors…

Bonamy HoltakNovember 3, 2014

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Fruit Bats and Flu

In the past, influenza A virus has been found in fruit bats from Guatemala, Central America. A recent publication in PloS Pathogens, has found similar viruses in bat species…

Bonamy HoltakOctober 31, 2014

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Efficient 1-step radiolabeling of monoclonal antibodies for targeted radioimmunotherapy treatment of cancer

Radioimmunotherapy treatment options for cancer patients are not without their own difficulties such as damage to surrounding non- cancerous cells and treatment side effects. Now radionuclides attached to antibodies have…

Bonamy HoltakOctober 29, 2014

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Characteristics of memory B Cells following HPV vaccination Immunity

As there are certain pathogens, such as HIV, whose risk to safety prevents the development of live or attenuated vaccines, the need for the development of subunit vaccines becomes more…

Bonamy HoltakOctober 22, 2014

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Immune-suppressant vaccine c blocks SIV infection in macaques

A novel vaccine that can be administered orally has been shown...

Bonamy HoltakOctober 9, 2014

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Short-term changes in HIV viral load and CD4+ cell count

HIV infection in antiretroviral therapy (ART)-naive individuals is typically characterized by a rise...

Bonamy HoltakOctober 7, 2014

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Club cells – identified in Influenza pathogenesis

The immune system's response to most viral infections, including influenza, is to kill and remove the pathogen. Eliminating infected cells rids the body of the infection. This murine study reports…

Bonamy HoltakSeptember 15, 2014

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Mother–Infant HIV Transmission a review on antibody protection

Despite the intimate relationship between a mother and her fetus only one third...

Bonamy HoltakAugust 27, 2014

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Eradication of metastatic mouse cancers by suppression of myeloid-derived cell

Although our immune system protects us well against infection it is less successful against cancer. In part, this is because cancer cells have developed immune evasive techniques. A therapeutic…

Bonamy HoltakAugust 25, 2014

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A link between penicillin treatment in newborn infants and obesity

Early life is a critical window of host-microbe metabolic interaction. The seeding of the intestinal microbiota begins at birth, and a stable microbial community is important for a well-functioning immune…

Bonamy HoltakAugust 19, 2014

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Efficacy of HPV vaccination in HIV positive adolescents and young adults

Human papillomavirus (HPV) is a common sexually transmitted infection that causes abnormal cell growth. High-risk strains, including type 16 and 18, can cause cervical and anal cancer. People typically become…

Bonamy HoltakJuly 30, 2014

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Infectious Disease in Africa Symposium

Only a few more days left to apply for the 5th Infectious Disease in Africa symposium...

Bonamy HoltakJuly 29, 2014

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Lopinavir/Ritonavir-based ART vs Efavirenz-based ART for the prevention of malaria in pregnancy

Based on previous research it has been suggested that protease inhibitors might produce...

Bonamy HoltakJuly 21, 2014

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Viral reservoirs limited by ART

A study on viral reservoirs in rhesus macaque monkey...

Bonamy HoltakJune 30, 2014

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Characterization of pandemic influenza immune memory after vaccination or infection

Influenza A infection is still a major infectious disease that has appreciable morbidity and mortality as evidenced during the pandemic in 2009. Furthermore antibody responses acquired after natural infection or…

Bonamy HoltakJune 25, 2014

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ART in acute infection limits viral reservoirs

This study from the vaccine and gene therapy institute in Florida looked at the effect of early treatment on viral reservoirs in rhesus macaque monkeys infected with SIV, a primate…

Bonamy HoltakJune 23, 2014

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Kaposi Sarcoma treated with pegylated interferon

Kaposi Sarcoma (KS) is the most common AIDS-defining cance...

Bonamy HoltakJune 20, 2014

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HIV sexual transmission risk among serodiscordant couples

A mathematical model of the current knowledge about the efficacy...

Bonamy HoltakMay 30, 2014

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Prostate cancer incidence among HIV-positive and HIV-negative men

studies have shown that HIV positive men have a lower reported incidence of prostate cancer...

Bonamy HoltakMay 27, 2014

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Vaccine-induced myeloid cell population dampens protective immunity

Studies have shown that vaccine-induced T cell responses are able to control the replication of HIV...

Bonamy HoltakMay 23, 2014

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Risk of Melanoma in People with HIV/AIDS

Results from a meta-analysis of 21 studies that looked at the association...

Bonamy HoltakApril 30, 2014

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New experimental vaccine looks promising for Dengue Fever

Apr 29, 2014 A new experimental vaccine for dengue fever has succeeded in its first late-stage clinical trial...

Bonamy HoltakApril 29, 2014

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New TB drug combination to enter late-stage testing

A new phase lll trial called Stand (Shortening Treatments by Advancing Novel Drugs)...

Bonamy HoltakApril 25, 2014

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Control of Malaria-Induced Inflammation in Children is Dependent on Exposure.

Primary exposure to P. falciparum can result in high levels...

Bonamy HoltakApril 24, 2014

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Clec12a regulates inflammation in response to cell death

The innate immune system has the ability to sense and respond to dead cells. Allowing the immune system to control non-infectious inflammatory responses. To better understand the mechanics of this…

Bonamy HoltakApril 22, 2014

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Results from a novel flu vaccine

Influenza pandemics, such as the H1N1 (swine flu) outbreak in 2009...

Bonamy HoltakApril 17, 2014

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Using immunomics to find vaccine antigens for schistosomiasis

Although schistosomiasis or bilharzia kills almost half a million people per year...

Bonamy HoltakMarch 31, 2014

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Understanding molecular evolution of HIV and ART

Antiretroviral therapy (ART), although known to be effective for preventing the onset of AIDS does not cure HIV...

Bonamy HoltakMarch 25, 2014

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Neuronal ferritin heavy chain and opiate abuse affect HIV-associated cognitive dysfunction

The chemokine CXCL12 and its cognate receptor CXCR4 perform multiple functions...

Bonamy HoltakFebruary 27, 2014

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Treating rhematoid arthritis with peptide-specific CD8+ regulatory T cells

The autoimmune disorder rheumatoid arthritis (RA) is characterized by joint inflammatio...

Bonamy HoltakFebruary 25, 2014

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Tolerance or resistance to HIV infection? Which is it?

Tolerance in biology can have different meanings, depending on context...

Bonamy HoltakFebruary 25, 2014

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T cell repertoire following autologous stem cell transplantation for multiple sclerosis

Autologous haematopoietic stem cell transplantation (HSCT) is typically used in haematologic ...

Bonamy HoltakFebruary 20, 2014

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Sex difference noted in response to influenza vaccine

Immune responses to infections and vaccinations have shown females...

Bonamy HoltakJanuary 31, 2014

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Normalizing glycosphingolipids restores CD4+ T cells function in lupus patients

The autoimmune rheumatic disease systemic lupus erythematosus (SLE) has been shown to...

Bonamy HoltakJanuary 30, 2014

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Microbiota helps regulate behaviour in Autism Spectrum Disorders

A number of studies have suggested a role for disturbances in the gut microbial balance ...

Bonamy HoltakJanuary 27, 2014

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Thibela TB study – a trial of mass Isoniazid preventive therapy for tuberculosis control

Results from a much anticipated community-based study into the effectiveness of Isonniazid...

Bonamy HoltakJanuary 24, 2014

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A systematic review and meta-analysis of long-term immune responses to vaccination in HIV

Initial immune responses to most vaccines are impaired in people with HIV. However, little is known about the persistence of vaccine-induced antibodies over the long-term. A team of French writers…

Bonamy HoltakJanuary 23, 2014

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