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Researchers have uncovered a key mechanism controlling CD8⁺ T cell infiltration into atherosclerotic plaques, highlighting a potential therapeutic target for cardiovascular disease...

CAR-T cell therapy, a efficient form of cancer immunotherapy, has revolutionised treatment for many patients with aggressive blood cancers. But while the therapy has led to remarkable long-term remissions, some…

Chikungunya virus infections are often acute, but for 30% to 60% of patients, especially women, the virus leaves a troubling legacy: chronic, severe joint pain that can persist for years.…

T cells are essential defenders of the immune system, but in some cases, their activity turns against the body—damaging healthy tissues and triggering autoimmune diseases like type 1 diabetes and…

New research reveals that even short-term exposure to a high-fat diet can immediately impair gut immunity—long before any physical symptoms appear (Figure 1). The study offers the first direct evidence…

The adoption of a healthy lifestyle can lead to significant improvements in physical and mental health. While vegetarian diets are often associated with health benefits, few studies have focused on…

The rising prevalence of metabolic syndrome (MetS) globally, dietary approaches such as vegan diets are becoming central to prevention and management strategies. Metabolic syndrome is characterized by a cluster of…

As cardiovascular diseases (CVD) remain a leading cause of mortality worldwide, dietary interventions have gained prominence in preventive health. A vegan diet, characterized by an abundance of fruits, vegetables, whole…

Crohn’s disease and ulcerative colitis affect different regions of the digestive tract but share common features: painful abdominal cramps, diarrhoea, weight loss, and fatigue. These symptoms often arise in cycles,…

Sepsis affects millions worldwide and is responsible for roughly 20% of global deaths. Traditionally, it was thought that sepsis-related mortality was due primarily to an excessive inflammatory response that damages…

HIV and malaria co-infections remain a significant public health issue in areas where both diseases are prevalent. Neutrophils, traditionally considered as rapid responders in the immune system, show diverse functional…

The battle against malaria has led to various strategies, with malaria transmission-blocking vaccines (TBVs) emerging as a promising approach. TBVs do not directly protect the vaccinated individual but work by…

A comprehensive meta-analysis recently explored the association between breastfeeding and mental health outcomes, evaluating the risk of mental disorders such as depression and anxiety in both mothers and children. This…

The COVID-19 pandemic has led to a significant rise in mental health challenges worldwide, with anxiety, depression, and other psychological disorders becoming increasingly prevalent. In a recent editorial published in…

Recent research has revealed a strong link between social status loss and depressive-like behaviours in both humans and animals. A study published in Cell explored this phenomenon using a novel,…

Rheumatoid arthritis (RA) is a complex autoimmune disease characterized by chronic joint inflammation and progressive joint damage. While inflammation is a hallmark of RA, the role of iron overload and…

Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes joint damage and reduces quality of life. Most RA treatments focus on managing symptoms after the onset of the disease.…

Rheumatoid arthritis (RA) is an autoimmune disease driven by complex interactions between immune cells in the synovium, the tissue lining the joints. A study published in Nature Communications (2024) sheds…

Traditionally, the innate immune system—the body’s first line of defence—was thought to lack the ability to "remember" past threats. Unlike the adaptive immune system, which can recognize and attack pathogens…

Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints, leading to pain, swelling, and joint damage. T cells play a critical role in RA’s progression,…

On World Sepsis Day 2024, survivors of sepsis and patient advocacy groups came together to launch the Paris Declaration, a call to action directed at European leaders. Despite the significant…

Hrpes simplex virus 1 (HSV-1) infects over 3.8 billion people worldwide, according to the World Health Organization. HSV-1 is also linked to viral encephalitis (brain inflammation) and has been implicated…

HIV-1 is initially released from infected cells in an immature and non-infectious form. The virus structure is primarily composed of 2,000 copies of a rod-shaped protein called Gag, which must…

Press Release: CIMA Care GmbH on 4 March 2025   CIMA Health Academy collaborates with the Immunopaedia Foundation, South Africa`s pioneering non-profit organization in global immunology education. Launched in 2005…

Type 1 diabetes, which affects approximately nine million people worldwide, is caused by an autoimmune attack on insulin-producing islet cells in the pancreas. Islet transplantation has shown promise in restoring…

Antimicrobial resistance (AMR) continues to be one of the most pressing global health challenges, with drug-resistant infections killing over 1.14 million people annually, surpassing the mortality caused by HIV/AIDS and…

Recent research has shown that omalizumab, a monoclonal anti-IgE antibody, significantly enhances tolerance to multiple food allergens. The treatment is particularly promising for individuals allergic to various foods, including peanuts,…

Food Protein-Induced Enterocolitis Syndrome (FPIES) is a non-IgE-mediated food allergy, which predominantly affects infants but can also impact adults. Unlike other food allergies, FPIES symptoms include delayed vomiting, lethargy, and…

Cancer immunotherapy trains immune cells—particularly tumour-infiltrating lymphocytes (TILs)—to recognize and eliminate tumour cells. However, many cancers develop strategies to evade immune detection, leading to treatment resistance. One major factor influencing…

CTLA4 is a key immune checkpoint involved in immune tolerance and cancer immunotherapy. Patients with CTLA4 deficiency experience immune dysregulation, resembling the adverse effects of immune checkpoint inhibitors used in…

Glucocorticoid-induced osteoporosis (GIOP) is a common and serious side effect of long-term glucocorticoid (GC) therapy, which is used to treat a variety of conditions including autoimmune diseases. GCs, while effective…

A recent study published in Annals of the Rheumatic Diseases explored the effects of L-arginine metabolism on arthritis and inflammation-induced bone loss. Rheumatoid arthritis (RA) is a chronic autoimmune condition…

A recent study sheds light on the immune mechanisms driving neutrophilic asthma and introduces one of the first mouse models designed to mimic the condition in humans (figure 1). Their…

Beta-glucan is a natural polysaccharide found in the cell walls of fungi, yeast, and grains like oats and barley. While traditionally recognized for its immune-boosting properties, this study demonstrates that…

In newborns, macrophages facilitate heart regeneration through a process called efferocytosis, where they engulf and remove dying cells. This process triggers the release of thromboxane A2, a bioactive lipid that…

Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are inflammatory conditions that affect older individuals, often causing significant morbidity. Until recently, treatment approaches for these conditions varied widely, leading to…

Osteoporosis, a condition affecting over 200 million people globally, is characterized by a loss of bone mineral density (BMD) and changes in bone microstructure. This makes bones more fragile and…

Glioblastomas (GBMs) are treatment-resistant, grade 4 brain tumours with remarkable immune evasion capabilities. At the core of GBM progression are tumour stem cells, a small but critical population (5-10%) that…

The small intestine plays a dual role—absorbing essential nutrients while preventing pathogens from invading the body. This creates a significant challenge for the immune system, as it must effectively detect…

Adverse food reactions are increasingly common in today's society, with conditions such as food allergies, intolerances, and celiac disease affecting a significant number of individuals. These reactions are rooted in…

A recent study published in Nature examined the role of tissue-resident memory CD8+ T cells (TRM) in preventing respiratory virus transmission, focusing on their ability to curb virus spread in…

Psoriasis is driven by an overactive immune system, with dendritic cells (DCs) playing a central role in triggering inflammation. A new study has identified a key protein, NF-kB c-Rel, that…

In a recent study published in Signal Transduction and Targeted Therapy, researchers have unveiled a novel approach to enhance the efficacy of CD8+ T cell-based immunotherapies against cancer (Figure 1).…

Post-polio syndrome (PPS) is a condition that affects polio survivors, often manifesting decades after the initial infection. A recent study published in the European Journal of Physical and Rehabilitation Medicine…

Stroke is a major health concern, with effects that extend beyond the brain. A recent study published in Nature Medicine reveals how brain injuries trigger long-term changes in immune responses…

T cells are a key component of the immune system's response to cancer. However, tumours create a hostile microenvironment that deactivates T cells, preventing them from producing cytokines—signalling molecules essential…

Food allergies are a significant public health issue, with individuals experiencing a range of reactions, from mild discomfort to life-threatening anaphylaxis. One of the key factors in managing food allergies…

While the global response to antimicrobial resistance (AMR) has largely focused on bacterial infections, a growing yet often overlooked threat is antifungal resistance. Fungal infections, which affect approximately 6.5 million…

Traditionally, blood sugar regulation has been attributed to the hormones insulin and glucagon, produced by the pancreas. Insulin lowers blood glucose by promoting cellular uptake, while glucagon raises it by…

Stroke is a leading cause of death and long-term disability, with ischemic strokes making up 85% of cases. Diagnosing stroke accurately and predicting disease progression remains challenging. In recent years,…

Stroke is a major global health issue, contributing to high mortality and long-term disability. As the population ages, understanding factors that influence stroke outcomes is crucial. A 2024 study, published…

Psoriasis is a hereditary, chronic inflammatory condition. While primarily recognized as a skin disease, it often co-occurs with joint inflammation and a heightened risk of chronic inflammatory bowel diseases (IBD)…

Rheumatoid arthritis (RA), a chronic inflammatory joint disorder and remains a challenging condition to treat effectively. Despite advancements in therapeutic options, many patients fail to achieve remission due to the…

Scientists have uncovered a new mechanism by which viral infections can trigger autoimmune diseases, overturning a long-standing theory (Figure 1). The study focuses on hepatitis C virus (HCV) and its…

Peste des petits ruminants (PPR) is a devastating viral disease affecting small ruminants, primarily sheep and goats, in many parts of the world, including Senegal. Vaccination is the key tool…

The rapid movement of people, animals, and food products, driven by globalization, presents a significant challenge to food security. Today, food security threats can arise in one part of the…

A recent study  has revealed the pivotal role of tristetraprolin (TTP), an RNA-binding protein, in controlling inflammatory responses in basophils, a type of immune cell central to allergic reactions (Figure…

Food allergies (FA) affect over 26 million people in the United States and place a significant burden on individuals and families. The challenges of managing FA extend beyond the physical…

The immune system's capacity for memory has long drawn comparisons to the brain’s cognitive memory. Just as the brain retains information and improves responses based on past experiences, the immune…

Respiratory syncytial virus (RSV) is a common respiratory virus that can cause severe infections, especially in infants, the elderly, and those with compromised immune systems. While the virus is typically…

Food insecurity (FI) is a significant and growing public health concern, particularly among older adults in the United States. Approximately one in four food-insecure households includes an adult aged 65…

Food insecurity (FI) is a significant and growing public health concern, particularly among older adults in the United States. Approximately one in four food-insecure households includes an adult aged 65…

In a ground-breaking study published in Viruses, researchers delve into the dual role of autophagy and apoptosis in the replication of the rabies virus (RABV). The intricate balance between these…

A new study has identified the amino acid asparagine as a critical regulator of germinal center (GC) B cells, which are essential for producing high-quality antibodies. The findings highlight the…

The gut microbiota is an integral component of the human body that is not only important for facilitating digestion and nutrient extraction, but is known to extend wide-ranging impacts on…

In a new study, researchers revealed a mechanism of digestive exophagy, which pave the way for therapies to enhance microglial plaque-clearing capabilities (Figure 1). Microglia, the immune cells of the…

The intricate relationship between inflammation and heart disease has been increasingly recognized in recent years, with inflammation playing a pivotal role in both the onset and progression of various cardiovascular…

The battle against heart failure and hypertrophy, particularly following a myocardial infarction, is one of the most significant challenges in cardiology. A recent study published in The Journal of Cellular…

Macrophages are immune cells critical to the lungs’ defence and repair processes. These cells are present in healthy lungs and are rapidly recruited during injury or disease. While macrophages are…

A recent study has revealed a new function for cellular RNA in regulating immune responses to RNA viruses, shedding light on how cells fend off infections. Research uncovers how specific…

Peripartum cardiomyopathy (PPCM) is a rare but serious form of heart failure that occurs during the last month of pregnancy or within the first few months postpartum. The condition is…

Heart failure (HF) is a complex and multifactorial disease that has increasingly been linked to inflammation. Over the past several decades, research has shown that inflammation is both a cause…

Takotsubo Syndrome (TTS), often called "broken heart syndrome," is a fascinating and complex condition in cardiology. In a recent review published in Frontiers in Immunology, researchers explored the immunological mechanisms…

Researchers have made significant progress in understanding how to optimize chimeric antigen receptor (CAR) T-regulatory cells (Tregs), a promising avenue for treating autoimmune diseases, improving organ transplant outcomes, and potentially…

Body mass index (BMI) has long been studied for its association with various health conditions, but its relationship with cognitive function and Alzheimer’s disease (AD) biomarkers remains inconclusive. A recent…

A new study offers important findings on severe allergic reactions, shedding light on the connection between alcohol and nut allergies while revealing patterns that could improve emergency care for all…

A comprehensive narrative review on emergency contraception (EC), published in the European Journal of Obstetrics and Gynaecology, provides a detailed overview of the different methods available for preventing pregnancy after…

A comprehensive questionnaire-based study commissioned by the European Board and College of Obstetrics and Gynaecology (EBCOG) and the European Society of Contraception (ESC) explored significant variations in the provision of…

Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME/CFS), has long puzzled researchers with its debilitating symptoms and unclear origins. In a new study researchers provide critical insights into…

In a recent study, published in the European Journal of Obstetrics & Gynaecology and Reproductive Biology, the authors present a rare case of prenatal ultrasound diagnosis involving multiple ocular malformations:…

In a new study researchers have developed a computational model that captures the complexities of placental antibody transfer, providing a pathway to more effective and equitable maternal immunisation strategies (Figure…

A ground-breaking study published in the European Journal of Obstetrics and Gynaecology examines the factors that influence contraceptive preferences among postpartum women in Brazil. The research was conducted at a…

Rabies remains a public health crisis, especially in high-burden countries like India. The recent publication in The Lancet Regional Health emphasizes the need for a shift from the current reliance…

Rabies remains a global health concern, causing thousands of deaths annually despite being preventable through vaccination. In their detailed review published in Open Veterinary Journal, Khairullah and colleagues explore the…

Malaria remains a critical global health challenge, claiming the lives of over 600,000 people annually, with African children under the age of five disproportionately affected. Severe malaria, caused by Plasmodium…

Gynaecological malignancies, including endometrial carcinoma (EC), cervical carcinoma (CC), and ovarian carcinoma, remain one of the important health burdens in females worldwide. These tumours represent one of the most common…

The fate of cells under stress—whether they survive or undergo programmed cell death—relies heavily on their mitochondria. Researchers have uncovered how a sudden halt in energy production within mitochondria prevents…

A recent study published in the European Journal of Obstetrics and Gynaecology highlights the unexpected connection between diabetic retinopathy (DR) and latent Toxoplasma gondii infection in pregnant Hispanic women. Toxoplasma…

Gestational diabetes mellitus (GDM) has been extensively studied due to its wide-reaching impact on maternal and foetal health. However, emerging research has begun to focus on its less visible consequences,…

A recent study has identified a novel link between immunosuppression in prostate cancer and a specialized subtype of epithelial cells, known as club-like cells (Figure 1). The research provides new…

The global fight against cancer reveals a stark contrast between high-income countries (HICs) and low- and middle-income countries (LMICs), with profound disparities in gynaecological cancer care. According to a recent…

In recent years, immunotherapy has revolutionised cancer treatment, offering hope for diseases previously considered incurable, such as melanoma, lung, and bladder cancers. By leveraging the body’s immune system to target…

Introduction Hematocrit, an essential indicator of blood health, is significantly affected in patients co-infected with HIV and malaria. This review delves into how co-infection impacts hematocrit levels, complicating disease progression…

Preterm birth, defined as delivery before 37 weeks of gestation, remains a significant cause of neonatal morbidity and mortality worldwide. Spontaneous preterm birth (sPTB), which accounts for a considerable portion…

Alzheimer’s disease (AD) is a devastating disease. An estimated 6.7 million Americans age 65 and older are living with AD today. This number could grow to 13.8 million by 2060.…

Prenatal alcohol exposure is a serious risk to fetal development, and South Africa has the highest documented prevalence of Fetal Alcohol Spectrum Disorders in the world. In response to the…

Antimicrobial resistance (AMR) is a growing global health threat that disproportionately affects low- and middle-income countries (LMICs) and vulnerable populations, including young children, older adults, and refugees. Effective antimicrobials are…

Hidradenitis suppurativa (HS) is a chronic and debilitating inflammatory skin condition that causes painful bumps or boils beneath the skin's surface, often in areas prone to sweating and friction, such…