Cheleka

breaking news

Not all RV144 vaccine induced IgA responses are bad.

28th March 2018 The RV144 or Thai Trial conducted in Thailand, is the only HIV vaccine trial to date that has demonstrated modest ...

ChelekaMarch 28, 2018

breaking news

Profiling MAITs during Multiple Myeloma

26th March 2018 Classical CD4 and CD8 T cell immunity have been the primary focus of understanding T cell immunity during cancer immunotherapy. Unlike classical T cells, unconventional cells are…

ChelekaMarch 26, 2018

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How does anti-TNF treatment affect TB granuloma formation?

23rd March 2018 Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is a significant problem, annually causing 1.7 million deaths worldwide. Although a significant proportion of the world population is estimated....

ChelekaMarch 23, 2018

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Immunoregulatory effects of Vitamin B5 during M.tb infection

19th March 2018 There is limited knowledge about the about the immunoregulatory effect of Vitamin B5, pantothenic acid, on the innate and adaptive immunity. Unlike Vitamin B5, vitamins A, C…

ChelekaMarch 19, 2018

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Oral vs intradermal BCG, what’s the difference?

16th March 2018 Bacillus Calmette-Guerin (BCG) vaccine was developed in 1921 to protect individuals from developing Tuberculosis (TB) and was initially administered orally.

ChelekaMarch 16, 2018

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Which cells contribute to immunity against vaginal Zika infection ?

15th March 2018 Knowledge of Zika virus (ZIKV) immunity in the genital tract is limited. Researchers from Washington University in USA aimed to determine if subcutaneous ZIKV infection protects against…

ChelekaMarch 15, 2018

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Can CXCL4 contribute to autoimmune pathology?

12th March 2018 Emerging research has shown increased levels of CXCL4, previously known as platelet factor 4, in various forms of T helper 17 (Th17) T cell associated rheumatic diseases.…

ChelekaMarch 12, 2018

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5GFTB Highlights: Human TB Challenge, is this possible?

9th March 2018 Eric Rubin from the Harvard T.H. Chan School of Public Health, is in the process of developing M.tb strains for human M.tb challenge models for TB vaccine…

ChelekaMarch 9, 2018

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5GFTB Highlights: Why is a new vaccine against TB important?

7th March 2018 The conference provided a wonderful platform on which the Indian government and research community to showcase its commitment to achieving the third United Nations Sustainable Development ....

ChelekaMarch 7, 2018

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5GFTB Highlights: MTBVAC potential BCG replacement

5th March 2018 Carlos Martin presented his research on the development of MTBVAC vaccine, a live attenuated M.tb strain from lineage 4 (Euro-African-American). Attenuation of the M.tb strain used in…

ChelekaMarch 5, 2018

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Article Highlight: Differentially Expressed Host linc RNA and mRNA in HIV-1 and HIV-2 Infection (Santanu et al., 2018)

2 March 2018 In the whole human genome, only 80% of genomic DNA is transcribed into RNAs that do not encode ...

ChelekaMarch 2, 2018

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5GFTB Highlights: Can we immunologically distinguish LTBI, EPTB and PTB

26th February 2018 Srabanti Rakshit, PhD candidate from the Indian Institute of Science, presented her work which aimed to determine unique T cell features that can distinguish LTBI, PTB and…

ChelekaFebruary 26, 2018

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5GFTB Highlights: Can we induce BCG-mediated long term innate immunity

23rd February 2018 Dr Maziar Divangahi highlighted one of his research groups recent publications (Kauffman et al.,) which aimed to determine if BCG vaccination can induce “long term” immunity against…

ChelekaFebruary 23, 2018

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5GFTB Highlights: Recombinant BCG-Esx1 can induce CD8 T cell responses

22nd February 2018 Dr Matthias I. Gröschel presented data at a plenary session of the 5th Global Forum on TB vaccines conference, on the development of a recombinant Mycobacterium bovis,…

ChelekaFebruary 22, 2018

Lab mouse of strain C57BL/6, female, 22 months of age, while eating a crumb of cake. Au: Alex Weingarten, Wikimedia Commons

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CD45.1 vs CD45.2 B6 mice more than an isoform difference.

19th February, 2018 Researchers determined differential murine immune response sand survival of CD45.1 and CD45.2 B6 mice infected with murine cytomegalovirus (MCMV), influence A and ...

ChelekaFebruary 19, 2018

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Potential therapeutic use of H. pylori for asthma

16th February, 2018 Helicobacter pylori is a bacteria that resides in the gut and is well known for its association with gastric ulcers, gastritis and gastric cancer. Recent studies highlight…

ChelekaFebruary 16, 2018

Bone marrow aspiration: Leishmaniasis (Leishmania sp.) in liver transplant recipient. Paulo Henrique Orlandi Mourao. Wikimedia Commons.

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Local signals matters: implication for CD8 T cell function against Leishmania

15th February, 2018 In response to Leishmania infection CD8+ T cells have been shown to produce IFN-γ, an essential cytokine required for control of infection. However, studies have shown that…

ChelekaFebruary 15, 2018

breaking news

Influenza-specific lung resident CD8+ T cells maintain diverse TCR profiles

12th February, 2018 CD8+ T cell immunity has been shown to induce cross-protective long lived immunity against different influenza strains.

ChelekaFebruary 12, 2018

breaking news

Influenza-specific lung TRM maintain diverse TCR profiles

12th February, 2018 CD8+ T cell immunity has been shown to induce cross-protective long lived immunity against different influenza strains.

ChelekaFebruary 12, 2018

Psoriatic arthritis. Source: James Heilman, MD, Wikimedia Commons

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ILCs homeostasis in Psoriatic Arthiritis

9th February, 2018 Researchers from Germany and Romania aimed to determine whether immune monitoring of innate lymphoid cells (ILCs) can be a potential alternative to biopsies to determine ...

ChelekaFebruary 9, 2018

breaking news

MAITs respond differently to ZIKV and DENV

7th February, 2018 Mucosal associated invariant T cells (MAITs) are a population of innate-like T cells that represent 1-10% of T cells in the blood of healthy adults. MAITs are…

ChelekaFebruary 7, 2018

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H5VLP-GLASE unlike H5VLP-alum induces both Ab and T cell responses

5th February, 2018 High antibody titres, specifically high hemagglutinination inhibition (HI) is a major criteria driving the licensure of egg-based inactivated influenza vaccines.

ChelekaFebruary 5, 2018

breaking news

Non-cytotoxic function of HIV-specific rectal CD8+T cells

2nd February, 2018 The Gastrointestinal mucosa is a major site of HIV transmission and pathogenesis. CD8 T cells play a major role in viral immunity against HIV infection. However, the…

ChelekaFebruary 2, 2018

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Measuring T cell proliferation using the “Warburg” effect.

31st January, 2018 Researchers from the University of Cambridge aimed to use naturally occurring changes in cellular metabolism to measure...

ChelekaJanuary 31, 2018

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Re-developed live attenuated Cholera vaccine, is it safe?

29th January, 2018 An effective vaccine against cholera could have a great impact in reducing morbidity and...

ChelekaJanuary 29, 2018

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Is kick-and-kill HIV cure strategy achievable?

26th January, 2018 Translation of the kick-and-kill strategy into clinical trials has not yet been successful. The lack of .....

ChelekaJanuary 26, 2018

breaking news

T-bet expression negatively affects T cell lung homing during TB

25th January, 2018 Researchers led by Daniel Barber from the National Institutes of Health (USA) aimed to determine factors...

ChelekaJanuary 25, 2018

breaking news

T follicular helper cells are essential for generating nAb during chronic-infection.

22nd January, 2018 Chronic viral infection is associated with high viral load which can lead to T cell dysfunction of CD8 and Th1 CD4 T cells. During ...

ChelekaJanuary 22, 2018

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HIV Env immunogens elicit broad antibody responses in animal models

19th January, 2018 One goal in HIV vaccine research is the development of an antibody-based vaccine to prevent HIV acquisition. Eliciting antibodies...

ChelekaJanuary 19, 2018

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Immunological T and B cell Diversity of the Human Penis

17th January, 2018 The male genital tract is a portal of entry for many sexually transmitted infections (STIs). One of main strategies to reduce incidence of STIs...

ChelekaJanuary 17, 2018

Fainsod-Levi et al. 2017 Cell Reports, Graphical Abstract

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How does hyperglycemia lead to aggressive cancer?

15th January, 2018 Several studies have suggested that diabetes and hyperglycemia increases the risk of developing breast cancer and metastatic disease, as.....

ChelekaJanuary 15, 2018

Twinrix GlaxoSmithKline combined vaccines hepatitis A (inactivated) + hepatitis B (recombinant S antigen) with Terumo needle and syringes (Wikimedia Commons)

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We need new HAB/HBV vaccine strategies for HCV/HIV infected individuals.

12th January, 2018 Hepatitis A (HAB) and/or Hepatitis B (HBV) virus infection is common in Chronic Hepatitis C virus (HCV) and/or HIV infected individuals.

ChelekaJanuary 12, 2018

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Dengue specifc-CD8 T cell responses but not Abs provide protection against Zika

10th January, 2018 Aedes aegypti mosiquito is vector for many flaviviruses including Dengue (DENV) and Zika (ZIKV) virus. Emergence of ZIKV in the America’s has...

ChelekaJanuary 10, 2018

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Patho-physiological implication of NET in COPD patients

8th January, 2018 Neutrophils contribute to airway damage in COPD patients by releasing proteases and reactive oxygen species which can increase mucus production and...

ChelekaJanuary 8, 2018

breaking news

Phase 1 Zika vaccine trial shows promise

5th January, 2018 As of November 2017, there are 7 potential Zika vaccines consisting of one mRNA, one peptide, one recombinant viral, two DNA and two inactivated viral vaccines.Women of…

ChelekaJanuary 5, 2018

Southern Africa Map with WGS illustration

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SAHGP Pilot: Southern Africans are more diverse than expected

3rd January, 2018 African populations are the most genetically diverse population and suffer the highest health burden in the world. However, genome studies of disease association rarely include...

ChelekaJanuary 3, 2018

breaking news

Whole M.tb inherently induce highly differentiated T cells compared to H56 vaccination

29th December, 2017 CD4 T cells, particularly those capable of producing IFN-γ have been shown to play an essential role in immunity...

ChelekaDecember 29, 2017

breaking news

Kai 1 and Kai 2, new Dog Erythrocyte Antigens: implications for clinical practice

27th December, 2017 Sensitising dogs with canine allogenic blood has enabled the identification of Dog Erythrocyte Antigens (DEA), which are clinically important regarding blood transfusion....

ChelekaDecember 27, 2017

Adaptation of T-cell dependent CD40L activation

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Expression of CD40L by CD8 T cells promotes autologous activation and differentiation

22nd December, 2017 CD40L plays an essential role during DC licensing – T cell mediated activation of Dendritic Cells (DC) and monocytes -, a process required for DCs to...

ChelekaDecember 22, 2017

Localisation of Pet-ESAT6 in RASV strains adapted from Sevastsyanovich et al. 2017 Fig 1C

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Vaccine induced T cell immunity, antigen localisation in bacterial vector matters

20th December, 2017 Attenuated bacterial vaccines are able to induce protective immunity against diseases. There has been interest in using Recombinant attenuated..

ChelekaDecember 20, 2017

Ebola virus budding from Monkey Cell line

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Functional antibody immunity 40 years post Ebolavirus exposure

15th December, 2017 Ebola virus diseases is caused by Ebolavirus spp, of which the Ebolavirus Zaire (EBOV-Zaire) is the most virulent and responsible for numerous Ebola outbreaks....

ChelekaDecember 15, 2017

Bacteria adhering to vaginal epithelial cells known as “clue cells”.

breaking news

Immunomodulatory effect of lactic acid on the female reproductive tract

13th December, 2017 The female reproductive tract (FRT) has numerous physiological and immunological barriers against HIV infection. In addition to being a physical barrier..

ChelekaDecember 13, 2017

breaking news

Elevated Th17 cells in “healthy” overweight children

11th December, 2017 Schindler et al. demonstrated an elevated Th17 cell function in overweight children in the absence of chronic inflammatory disease or infection....

ChelekaDecember 11, 2017

Confocal Microscopy Image of naive CD8+ and LIST-OVA-specific CD4 T cells

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Transphagocytic CD4+ T cells are true APC capable of inducing functional CD8 memory cells

8th December, 2017 Cruz-Adalia et al. demonstrated that tpCD4 T cells are capable of priming naïve CD8 T cells, that have a predominantly...

ChelekaDecember 8, 2017

breaking news

Potential serological test capable of distinguishing Zika from Dengue infections

6th December, 2017 Antibodies play an integral role in immunity against flavivirus infection and disease, making them ideal targets for serological diagnosis of flavivirus infections.

ChelekaDecember 6, 2017

breaking news

RTS,S/AS01E induces robust central memory responses to HBsAg but not to CSP

4th December, 2017 Moncunill et al. demonstrated that RST,S/AS01E is capable of inducing CD4+ CSP- and HBsAg-specific memory cells in vaccinated children.

ChelekaDecember 4, 2017

breaking news

CD161+CD4+ T cells depleted at the Cervix during HIV Infection

1st December, 2017 Boily-Larouche et al., observed that HIV uninfected women had higher frequencies of CD161+CD4+ T cells in the cervix compared to blood...

ChelekaNovember 30, 2017

breaking news

IL-10+ Th1 T cells associated with reduced malaria parasitemia

17th November, 2017Boyle et al. showed that CD4+ IL-10 producing Pf-specific T cells are of Th1 origin and are associated with reduced parasitemia in children from a high malaria endemic…

ChelekaNovember 17, 2017

EM of Mycobacterium tuberculosis (Janice Carr, WIkimedia Commons)

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Pre-diabetes associated M.tb-specific T cell dysfunction

13th November, 2017Kumar et al. showed that individuals with PDM-LTBI had significantly decreased CD4+ Th1 T cell functionality compared to LTBI only individuals. This dysfunction was...

ChelekaNovember 11, 2017

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