Do neutrophils play a role in age-associated increase in flu mortality?
![Fig.1 Neutrophil depletion at the end of the first week p.i. (postinfection) enhances survival in aged mice. a Young mouse were administered a neutrophil-depleting monoclonal antibody just prior to inoculation with influenza virus and following infection (as described in Materials and methods) and survival was monitored. Compared to isotype control treated mice, neutrophil-depleted young mice exhibited a significant increase in mortality. *P < 0.05 (Log rank), n = 8–10 per group. b Aged mice were treated per a and survival postinfection was monitored. P value between neutrophil-depleted and control group, P=0.23 (Log-Rank). n=8–10 per group. c Young mice were administered a neutrophil-depleting antibody at day +6 p.i., then intermittently until day +12 p.i. (as described in Materials and methods) and compared to isotype control treated, young infected mice. *P = 0.10 (Log-rank), n = 8–10 per group. d Aged mice were treated according to c and survival was measured postinfection. Aged neutrophil-depleted mice exhibited a significant increased survival as compared to the control group. *P < 0.05 Log-rank, n = 8–10 per group]()
Influenza virus infection causes more mortality in elderly compared to younger people, and one of the main reasons could be aging of the immune system. Aging impairs both innate ...
ChelekaMarch 8, 2019
![Early T cell–dependent PBs form in the absence of single dif- ferentiated CD4+ T cell subsets. (A) Identification of PE+ cells among CD90.22CD11c2F4/802Gr-12 cells (left panel) from PE-enriched spleen and lymph node samples from WT mice immunized with 2W-PE in CFA 11 d earlier. The middle and right panels show gates used to identify PE-specific PBs (B220lowIgG [H+L]high) or GC B cells (B220highCD382GL7+). (B) Numbers of PE-specific total (left panel) and GC B cells (right panel). (C) Gating and (D) numbers of IgM2IgD2 PBs. Data are expressed as the mean value and repre- sentative of two independent experiments (n = 2–6 mice/group). The p values were obtained from a one-way ANOVA and Dunnett posttest that compares all groups with the WT control group. *p , 0.05, ***p , 0.001.](https://new.immunopaedia.com/wp-content/uploads/2018/12/191218.png)
