Cheleka

Scientists from USA have recently reported on the first human phase I clinical trial that tested the safety of using CRISPR edited immune cells in patients with advanced cancer. CRISPR-Cas9…

Functional activity by tumor-associated macrophages (TAMs) contribute to an immunosuppresive micro-environment that inhibits killing of cancerous cells. TAMs have been associated with poor prognosis of cancer patients on immunotherapy. Thus…

Active mutations in KIT tyrosine kinase are found in several cancers, such as acute myeloid leukemia (AML). However, the different locations in the AML cells where KIT induces cancer-specific signaling…

Sánchez-Reyes et al., evaluated the effect of supernatants from cerival cancer derived-cell lines on the phosphorylation of STAT1, NF-kb-p65 and STAT6 and the impact in the secretion profile of cytokines…

Study lead by Prof Ryushin Mizuta, have now discovered exactly how cfDNA is generated. They also talk about the applications of DNase1L3-the enzyme mainly responsible for generating cfDNA-as a novel…

Day 4 of Immuno-Jaipur included talks by Oliver Boyer and Hannes Stockinger. Prof. Olivier Boyer lecture highlighted the origin and perspectives of CAR-T cells for treatment of cancer patients. He briefed…

In addition to talks by Prof Abbas, Day 3 of Immuno-Jaipur included talks on autoimmunity and chronic inflammation. Prof. Bernhard Fleisher gave a talk on autoimmunity in the central nervous…

Early detection of breast cancer offers curable options, however, once metastasized the cancer cannot be cured. With higher rates of breast cancer correlated with western diet consumption...

Cervical cancer, one of the top 5 common cancers in women globally, is often associated with high-risk human papillomavirus (HPV) infections such as oncogenic HPV16 and HPV18.

27August Researchers in South Korea have identified a new method for treating difficult cancers using state-of-the art liposome technology. The purpose of the study was to demonstrate the utility of…

Osteoclasts (OCLs) are multi-nucleated phagocytes of monocytic origin that are responsible for bone resorption. Changes in their bone resorption function are associated with various pathologies such as osteoporosis, chronic inflammation…

Neutrophils have been implicated in tumor pathology, where studies have reported a positive association between high neutrophil levels and tumor progression. Researchers from Europe (Ponzetta et al.,) aimed to determine...

Prior to the study by Professor De Bono and colleagues, no previous study had considered the use of Tisotumab Vedotin, a tissue factor-specific human monoclonal antibody as a treatment option…

Castellano et al., demonstrated the importance of glutamine and glutamate to the survival of these latently-infected macrophages by showing that there was a decrease in the number of cells that survived...