Cheleka

Darrah et al., showed that BCG-IV resulted in superior T cell and antigen-presenting cell recruitment to the lung compared to other vaccination strategies. In addition to T cell and innate immunity, BCG-IV also induced…

Research led by Dr Flynn aimed to determine if CD4 T cells are necessary for protection against reinfection. To test this hypothesis, CD4 T cells were depleted in infected and…

Can we determine host immune responses associated with resolving (sterile) and permissive (M.tb growth and eventual dissemination) granulomas? This summary highlights recent findings that suggest immune signatures associated with M.b…

We highlight a recently published study by Thacker et al., 2020, which utilised the lung-on-a-chip to understand the role of surfactants during the early stages of Mycobacterium tuberculosis (M.tb) growth.…

Researchers sought to identify mechanisms that can account for the increased susceptibility to tuberculosis disease among individuals with diabetes and intermediate hyperglycemia. They demonstrated that patients with intermediate levels of…

Researchers from India and United Kingdom utilised human samples to demonstrates that NIX plays a central role in mitophagy mediated immune and metabolic reprogramming of peripheral immune cells during chronic…