Bonamy Holtak

Kawasaki disease is the most common cause of acquired heart disease in children, however the cause remains unknown. Both infectious and environmental agents are considered as possibilities. In this study…

  HIV is a persistent viral infection and even in the presence of an effective antiretroviral treatment (ART) regimen, the virus hides in a latent state. In the 1st August…

Respiratory syncytial virus (RSV) can produce acute respiratory illness in patients of all ages, but strikes the age extremes, infants and the elderly, with highest frequency. Accounting for approximately 64…

The long term persistence of latently infected resting memory T-cells in HIV-infected patients is an important barrier to cure. Therefore finding a way to overcome and eliminate latently infected cells…

An article in this week’s British Journal of Medicine discussed a longitudinal study conducted over 20 years, that looked at antibiotic treatment failure in a primary care setting. Bacterial resistance…

Streptococcus agalactiae (Group B Streptococcus, GBS) is a commensal of the digestive and genitourinary tracts of humans that emerged as the leading cause of bacterial neonatal infections in Europe and…

Regulatory T cells (Tregs), which express CD4 and FOXP3, are critical for modulating the immune response and promoting immune tolerance. It is therefore of great therapeutic importance to find ways…

Although Epstein Barr virus (EBV) infections typically remain asymptomatic, in a small percentage of patients the virus causes B cell lymphomas and carcinomas. Additionally symptomatic primary EBV infection, called infectious…

Although antiretroviral therapy improves the health of HIV infected individuals, current therapies are still unable to cure infection. Furthermore, it has become clear that antiretroviral therapy does not completely restore…

Despite how common the human skin disease acne vulgaris is we still lack a curative treatment that targets overproduction of sebum, unwanted sebocyte proliferation and inflammation without side effects. One…

Boosted protease inhibitor and nucleoside reverse transcriptase inhibitors (NRTIs) is a regimen that is often used as a first line treatment regimen as it has the advantage of rarely resulting…

Bacteria colonise environments by forming biofilms, which are extremely resistant to conventional antibiotics. For this reason biofilms are the cause of many infections, particularly where there are device-related infections, infections…

Physiological wound healing is divided into the sequential, yet overlapping, stages of haemostasis, inflammation, proliferation, and remodeling. The proliferative phase is characterized by granulation tissue formation, collagen deposition, reepithelialization, and…

Although commonly encountered, respiratory syncytial virus (RSV) infection which is responsible for more than sixty million cases of respiratory disease worldwide each year, has no effective prophylactic or treatment regimen…

Cigarette smoke is the most common cause of pulmonary emphysema, which results in an irreversible loss of lung structure and function. Lung myeloid dendritic cells (mDCs) derived from cigarette smokers…