January 2026

Mycobacteria such as Mycobacterium tuberculosis can survive and multiply inside immune cells called macrophages, but how they achieve this has remained unclear. New research reveals that these bacteria hijack a…

A new pilot study suggests that prolonged exposure to airborne pollen, particularly ragweed, may worsen symptoms and quality of life in people with chronic rhinosinusitis (CRS). The research found that…

A large population-based study suggests that receiving the shingles vaccine may be associated with slower biological aging at the molecular level (Figure 1). Researchers analysed data from nearly 4,000 U.S.…

Large population study identifies metabolic signatures that improve early risk prediction (Figure 1). Figure 1: Study overview. a, To identify blood metabolites associated with incident T2D, we analyzed 469 harmonized…

Chronic, low-grade inflammation is a defining feature of obesity and a major contributor to diseases such as type 2 diabetes, fatty liver disease, cardiovascular disorders, and cancer. New research reveals…

New research identifies the immune cells that travel from skin to joints and why they trigger disease in some patients (Figure 1). Figure 1: CD11b+ myeloid cells migrate from the…

New studies show that preserving lymph nodes may be critical for effective anti-tumour immune responses (Figure 1). Figure 1: LNs preserve the stemness, proliferative fitness and polyfunctionality of T cells.…

New research reveals that CD8⁺ T cells rely on caspase-8 to control Toxoplasma infection in the brain (Figure 1). Figure 1: Caspase-8 is essential for controlling T. gondii infection in…

A comprehensive single-cell atlas reveals how tissue environment and time shape eosinophil identity across the body (Figure 1). Figure 1: Single-cell transcriptomics analysis identifies tissue-specific eosinophil states. a, Schematic diagram…

New research uncovers how tumours use TGF-β to build a powerful double barrier against the immune system and how it might be dismantled (Figure 1). Figure 1: Inhibition of T…

Researchers find that calcium alpha-ketoglutarate restores key brain functions disrupted by Alzheimer’s in preclinical models (Figure 1). Figure 1: CaAKG ameliorates impaired LTP in APP/PS1 mice with a more profound…

Researchers use a temporary “liver factory” to restore T cell strength in older mice (Figure 1). Figure 1: Hepatic reconstitution of declining T cell signalling factors to restore immune signalling…

New analysis suggests immune signatures can guide safer, more effective checkpoint inhibitor combinations in melanoma (Figure 1). Figure 1: Graphical abstract. Immune checkpoint inhibitors (ICIs) have transformed melanoma treatment, but…

New research links oral bacteria to disability severity in MS, pointing to a possible “oral–brain axis” (Table 1). Table 1: Proportion of patients with high and low relative abundances of…