December 2025

New research shows that beneficial bacteria train the maternal immune system to tolerate the developing fetus (Figure 1). Figure 1: Graphical abstract. Pregnancy poses a remarkable immunological challenge: the mother’s…

A new deep-learning framework combines protein language models and 3D structure to accelerate vaccine antigen discovery. Vaccines remain the most powerful tool for preventing infectious diseases but designing them is…

Clinical trial data show nemolizumab eases itch and improves sleep within days for people with severe eczema and prurigo nodularis (Figure 1). Figure 1: Graphical abstract. For people living with…

New strategies aim to overcome the biggest barrier to CAR-T success beyond blood cancers (Figure 1). Figure 1: Key features that prevent CAR-T cells from infiltrating solid tumors through the…

New research reveals that deadly filoviruses directly infect intestinal cells, disrupting fluid balance and driving life-threatening diarrhoea (Figure 1). Figure 1: Directed differentiation of human iPSCs into region-specific intestinal (HIOs)…

Researchers uncover “pseudo leukotrienes” that could reshape how asthma and inflammatory diseases are treated (Figure 1). Figure 1: Graphical abstract. For decades, asthma has been explained by a familiar culprit:…

Researchers uncover how chemotherapy-like strategies may selectively eliminate HIV-infected immune cells (Figure 1). Figure 1: Antiproliferative drugs abrogate the proliferation of HIV-1–infected cells reactive to Gag peptides. (A) Schematic representation…

New research links poor sleep and anxiety to reduced natural killer cells in young adults (Figure 1). Figure 1: Anxiety has a negative influence on the percentage of peripheral NK…

A new study identifies “mitoxyperilysis,” a previously unknown cell death pathway that could be harnessed to treat cancer (Figure 1). Figure 1: Graphical abstract. In many diseases, from infections to…

New ANAcare report offers clinicians a practical roadmap for accurate, consistent diagnosis of IgE-mediated food allergy (Figure 1). Figure 1: Typology of IgE-mediated, non–IgE-mediated, and mixed-type food allergies. Diagnosing food…

New research shows that dietary iron deficiency impairs antiviral immunity in the lungs and the effects may persist even after iron levels return to normal (Figure 1). Figure 1: Mouse…

New research shows that protecting infants from RSV could prevent asthma later in life. A major international study has uncovered compelling evidence that respiratory syncytial virus (RSV) infection in early…

The study titled “Multilevel systems biology analysis identifies key immune response profiles and potential correlates of protection for the M72/AS01E vaccine against tuberculosis” applies an integrated computational framework to characterize…