November 2025

Scientists develop a non-invasive nanomedicine that delivers immune-stimulating therapy directly to brain tumours (Figure 1). Figure 1: cGAS-agonistic ISD45-SNAs activate the cGAS-STING pathway in murine macrophages. (A) Schematic of the…

In a recent study, researchers uncover how changes in joint immune cells may explain treatment resistance in rheumatoid arthritis. Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes painful…

New research reveals an unexpected immune-driven cause of chemotherapy-induced nerve damage and a possible way to prevent it (Figure 1). Figure 1: Paclitaxel activates IRE1α in immune cells in the…

Scientists discover the molecular switch that drives tissue-resident memory T cell development, opening new doors for cancer, infection, and autoimmune therapies. Our immune system relies on a hidden army of…

Recent advances in single-cell technologies and immune profiling have revealed just how diverse T-cell populations are. They exist far beyond the classic “CD4 helper” vs “CD8 cytotoxic” labels. But the…

New “protein-degrading” compounds show promise against aggressive pancreatic and gastrointestinal cancers (Figure 1). Figure 1: Graphical abstract. Pancreatic cancer remains one of the deadliest malignancies, notoriously resistant to chemotherapy and…

A recent study reveals how Epstein–Barr virus reprograms immune cells to attack the body’s own tissues (Figure 1). Figure 1: EBV-seq enables identification of EBV-infected B cells. (A) An EBV-seq…

Researchers use artificial intelligence to create functional antibodies against deadly viruses, without needing a physical sample (Figure 1). Figure 1: Graphical abstract. A new study published in Cell demonstrates how…

A new longitudinal study tracked anti-wildtype SARS-CoV-2 spike IgG levels monthly in healthy adults from 2020 onwards, analysing responses after mRNA vaccinations and in the context of so-called hybrid immunity…

A new study uncovers how immune cells can exploit aberrant protein synthesis in cancer cells to identify shared, highly expressed targets for adoptive T-cell therapy (Figure 1). Figure 1: Graphical…

New research reveals how oxygen deprivation leaves a lasting genetic imprint on the body’s infection-fighting cells (Figure 1). Figure 1: ARDS induces long-term alterations of neutrophil phenotypes and functions. a–i,…

Brain tumours represent one of the greatest challenges in modern cancer immunotherapy. Unlike other malignancies, they develop within the brain’s immune-privileged environment, a highly protected space designed to limit inflammation…