February 2025

Recent research has shown that omalizumab, a monoclonal anti-IgE antibody, significantly enhances tolerance to multiple food allergens. The treatment is particularly promising for individuals allergic to various foods, including peanuts,…

Food Protein-Induced Enterocolitis Syndrome (FPIES) is a non-IgE-mediated food allergy, which predominantly affects infants but can also impact adults. Unlike other food allergies, FPIES symptoms include delayed vomiting, lethargy, and…

Cancer immunotherapy trains immune cells—particularly tumour-infiltrating lymphocytes (TILs)—to recognize and eliminate tumour cells. However, many cancers develop strategies to evade immune detection, leading to treatment resistance. One major factor influencing…

CTLA4 is a key immune checkpoint involved in immune tolerance and cancer immunotherapy. Patients with CTLA4 deficiency experience immune dysregulation, resembling the adverse effects of immune checkpoint inhibitors used in…

Glucocorticoid-induced osteoporosis (GIOP) is a common and serious side effect of long-term glucocorticoid (GC) therapy, which is used to treat a variety of conditions including autoimmune diseases. GCs, while effective…

A recent study published in Annals of the Rheumatic Diseases explored the effects of L-arginine metabolism on arthritis and inflammation-induced bone loss. Rheumatoid arthritis (RA) is a chronic autoimmune condition…

A recent study sheds light on the immune mechanisms driving neutrophilic asthma and introduces one of the first mouse models designed to mimic the condition in humans (figure 1). Their…

Beta-glucan is a natural polysaccharide found in the cell walls of fungi, yeast, and grains like oats and barley. While traditionally recognized for its immune-boosting properties, this study demonstrates that…

In newborns, macrophages facilitate heart regeneration through a process called efferocytosis, where they engulf and remove dying cells. This process triggers the release of thromboxane A2, a bioactive lipid that…

Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are inflammatory conditions that affect older individuals, often causing significant morbidity. Until recently, treatment approaches for these conditions varied widely, leading to…

Osteoporosis, a condition affecting over 200 million people globally, is characterized by a loss of bone mineral density (BMD) and changes in bone microstructure. This makes bones more fragile and…

Glioblastomas (GBMs) are treatment-resistant, grade 4 brain tumours with remarkable immune evasion capabilities. At the core of GBM progression are tumour stem cells, a small but critical population (5-10%) that…

The small intestine plays a dual role—absorbing essential nutrients while preventing pathogens from invading the body. This creates a significant challenge for the immune system, as it must effectively detect…

Adverse food reactions are increasingly common in today's society, with conditions such as food allergies, intolerances, and celiac disease affecting a significant number of individuals. These reactions are rooted in…

A recent study published in Nature examined the role of tissue-resident memory CD8+ T cells (TRM) in preventing respiratory virus transmission, focusing on their ability to curb virus spread in…

Psoriasis is driven by an overactive immune system, with dendritic cells (DCs) playing a central role in triggering inflammation. A new study has identified a key protein, NF-kB c-Rel, that…

In a recent study published in Signal Transduction and Targeted Therapy, researchers have unveiled a novel approach to enhance the efficacy of CD8+ T cell-based immunotherapies against cancer (Figure 1).…

Post-polio syndrome (PPS) is a condition that affects polio survivors, often manifesting decades after the initial infection. A recent study published in the European Journal of Physical and Rehabilitation Medicine…