March 2021

breaking news

HPV & HIV infection are associated with high levels of activated CD4 T cells in the cervix uteri

To dissect the effect of HIV and HPV on cervical immunity, Mbuya et al. analysed the expression of activation and memory markers on systemic and cervical T cells in relation…

ChelekaMarch 30, 2021

breaking news

Predicting tissue graft outcomes using immune markers

An Italian research team has recently shown that immune markers, CXLC10 and IL-6, are able to predict the viability of grafts taken from donor patients who have suffered brain death.…

ChelekaMarch 26, 2021

Protection against Mtb infection after IV BCG immunization. a, Lung inflammation (total FDG activity) and number of lung granulomas over the course of infection as measured by serial PET–CT scans. Each line shows one NHP over time; 3 NHPs (2 unvaccinated (unvax) and 1 IDlow) reached a humane end point before 12 weeks. tntc, too numerous to count. b, Three-dimensional volume renderings of PET–CT scans of each NHP at the time of necropsy. PET was limited to the thoracic cavity; the standardized uptake value colour bar is shown in the top right and indicates FDG retention, a surrogate for inflammation. (Source Darrah et al., 2020)

breaking news

JoAnne Flynn: BCG IV vaccination induces sterilising M.tb immunity.

Darrah et al., showed that BCG-IV resulted in superior T cell and antigen-presenting cell recruitment to the lung compared to other vaccination strategies. In addition to T cell and innate immunity, BCG-IV also induced…

ChelekaMarch 24, 2021

breaking news

Flynn Webinar: What immune cells play a role in protection against M.tb re-infection?

Research led by Dr Flynn aimed to determine if CD4 T cells are necessary for protection against reinfection. To test this hypothesis, CD4 T cells were depleted in infected and…

ChelekaMarch 19, 2021

breaking news

Flynn Webinar: Immune features associated natural infection

Can we determine host immune responses associated with resolving (sterile) and permissive (M.tb growth and eventual dissemination) granulomas? This summary highlights recent findings that suggest immune signatures associated with M.b…

ChelekaMarch 16, 2021

breaking news

BCG vaccination reduces infection in the elderly

Interim analysis of a BCG vaccination trial that aimed to determine if BCG induces non-specific protection against any infection demonstrated that elderly BCG vaccination is safe and reduces the incidence…

ChelekaMarch 12, 2021

breaking news

Exploratory study investigates the relationship between recent vaccinations and SARS-CoV-2 infection rates.

Pawlowski et al. analysed immunisation records of to determine if historical vaccination (within 5 years) afforded any protection against SARS-CoV-2 in individuals who received SARS-CoV-2 PCR tests.

ChelekaMarch 11, 2021

breaking news

Statins: improved survival rates and reduced mortality rate in COVID-19 patients.

Researchers carried out a literature search from January 2019 to December 2020 to identify studies that reported the association between statin usage and adverse outcomes, including mortality, ICU admissions, and…

ChelekaMarch 9, 2021

breaking news

Myeloid-derived suppressor cells: drivers of severe COVID-19 disease?

Scientists from Karolinska University investigated Monocytic Myeloid-derived suppressor cells (M-MDSCs) in COVID-19 patients across the spectrum of COVID-19 disease and compared this to influenza patients and healthy controls.

ChelekaMarch 5, 2021

breaking news

Webinar on harnessing innate immunity from cancer therapy to COVID-19

In this webinar, Eric Vivier describes novel immunotherapies that aim to improve cancer and COVID-19 pathogenesis by targetting promoting NK cell-mediated and blocking C5a mediated immunity, respectively.

ChelekaMarch 2, 2021

HPV & HIV infection are associated with high levels of activated CD4 T cells in the cervix uteri

Predicting tissue graft outcomes using immune markers

JoAnne Flynn: BCG IV vaccination induces sterilising M.tb immunity.

Flynn Webinar: What immune cells play a role in protection against M.tb re-infection?

Flynn Webinar: Immune features associated natural infection

BCG vaccination reduces infection in the elderly

Exploratory study investigates the relationship between recent vaccinations and SARS-CoV-2 infection rates.

Statins: improved survival rates and reduced mortality rate in COVID-19 patients.

Myeloid-derived suppressor cells: drivers of severe COVID-19 disease?

Webinar on harnessing innate immunity from cancer therapy to COVID-19

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