November 2020

breaking news

How does SARS-CoV-2 evade the immune defences?

As most of pathogens, SARS-CoV-2 can be recognized by PRRs on innate. Normally, this recognition helps the innate immunity to eliminate the infection or to activate the adaptive immune responses,…

ChelekaNovember 30, 2020

breaking news

Investigating Ebola immunity using single cell technologies

In a recent Cell article, Kotliar et al., utilise RNA-sequencing and mass cytometry to immune profile 21 rhesus monkeys before or during lethal Ebola virus challenge in vivo. This study…

ChelekaNovember 27, 2020

breaking news

Investigating the role of surfactants during TB using the lung-on-a-chip model

We highlight a recently published study by Thacker et al., 2020, which utilised the lung-on-a-chip to understand the role of surfactants during the early stages of Mycobacterium tuberculosis (M.tb) growth.…

ChelekaNovember 26, 2020

breaking news

Gut Inflammation Linked to a Debilitating Skin Condition

In their recent Frontiers in Immunology article, Yegorov et al., report that psoriasis patients have elevated levels of IL-1α, a cytokine central to the control of inflammation. In addition, the…

ChelekaNovember 24, 2020

breaking news

Safety and immunogenicity of Sputnik V vaccine

Overall the vaccine was safe, with the most common systemic and local reactions pain at the injection site, hyperthermia, headache, asthenia, and muscle and joint pain. Immunogenicity results from the…

ChelekaNovember 23, 2020

breaking news

SARS-CoV-2 mRNA-1273 vaccine shows signs of potential efficacy

Interim analysis on 95 cases of which 11 were severe cases all from the placebo group. Preliminary report of their Phase 1 Clinical trial demonstrated that vaccination with mRNA-1273 did not…

ChelekaNovember 19, 2020

breaking news

Pfizer and BioNTech COVID-19 vaccine

BNT162b1 is an mRNA based vaccine, co-developed by Pfizer and BioNTech was the first COVID-19 vaccine to release preliminary analysis that suggests >90% efficacy against COVID-19 infection in SARS-CoV-2-naïve adults.…

ChelekaNovember 17, 2020

breaking news

The role of Galectin-3 in the tumor microenvironment

Review describes the underlying potential immunosuppressive effect of gal-3 through his modulation of lymphocytes and macrophages activity, specifically in the prostate and lung cancer. Depending on its location, extracellular or…

ChelekaNovember 16, 2020

breaking news

Developing an oral polio vaccine that does not cause vaccine-associated polio

Researchers have modified the Sabin vaccine strain (nOPV2) making it less likely to regain virulence as the original Sabin strain. Genetic modification of nOPV2 did not affect the thermal stability,…

ChelekaNovember 9, 2020

breaking news

Meningeal-IgA+ plasma cells contribute to CNS-immunity

Fitzpatrick et al., aimed to profile steady-state meningeal humoral immunity and investigated the induction of humoral in the meninges. In their study, they showed that meninges of “healthy, unchallenged” mice…

ChelekaNovember 6, 2020

breaking news

Should we consider aerosol vaccines for COVID-19

Since SARS-CoV-2 is airborne, we would be better served by a vaccine that would be delivered intranasally in order to promote an IgA response that targets the virus at mucosal…

ChelekaNovember 4, 2020

breaking news

Testing potential neonatal sepsis drugs using a murine neonatal sepsis.

Using the E.coli neonatal sepsis model researchers demonstrated dissemination of E.coli to other parts of the body including the brain was also associated with detection of detrimental sepsis-associated inflammatory cytokines.…

ChelekaNovember 2, 2020

How does SARS-CoV-2 evade the immune defences?

Investigating Ebola immunity using single cell technologies

Investigating the role of surfactants during TB using the lung-on-a-chip model

Gut Inflammation Linked to a Debilitating Skin Condition

Safety and immunogenicity of Sputnik V vaccine

SARS-CoV-2 mRNA-1273 vaccine shows signs of potential efficacy

Pfizer and BioNTech COVID-19 vaccine

The role of Galectin-3 in the tumor microenvironment

Developing an oral polio vaccine that does not cause vaccine-associated polio

Meningeal-IgA+ plasma cells contribute to CNS-immunity

Should we consider aerosol vaccines for COVID-19

Testing potential neonatal sepsis drugs using a murine neonatal sepsis.

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