September 2020

breaking news

Safety and immunogenicity of the Ad26.COV2.S COVID-19 vaccine candidate.

Recent medRxiv pre-print reports on an interim analysis of an adenovirus type 26 SARS-CoV-2 vaccine candidate (Ad26.COV2.S). This was a phase 1/2a randomized, double-blinded, placebo-controlled clinical study consisting of a…

ChelekaSeptember 29, 2020

breaking news

Why do people with the Dantu blood group have a lower risk of developing malaria?

Kariuki et al., demonstrate that individuals with Dantu blood groups express RBC surface proteins that play a role in parasite invasion into the RBC (e.g. CGYPA, GYOC, Band 3) at…

ChelekaSeptember 28, 2020

breaking news

Boosting of antibody responses against the V2 and V3 region of the HIV-1 Env

In the presented article the authors assessed the effect of a late boost in sustaining these desired antibody responses towards the HIV-1 Env in a multi-clade, multigene HIVIS-DNA priming, and…

ChelekaSeptember 25, 2020

breaking news

SAIS/Immunopaedia COVID-19 Webinar on Severe vs mild COVID-19 immunity, and intersection between Nicotinamide pathway & COVID-19.

This article summarises webinar that featured talks by Prof Clive Gray: on severe vs mild/asymotmatic COVID-19 and Dr Melinda Suchard on Macrophage activation and Nicotinamide pathways in COVID-19.

ChelekaSeptember 23, 2020

breaking news

A mechanism for severe COVID-19 in patients with obesity and diabetes?

A recent review in eLife synthesises data from multiple studies to propose a synergistic interaction between SARS-CoV-2 infection and obesity and/or diabetes leading to impaired endothelial function and gut barrier…

ChelekaSeptember 22, 2020

breaking news

HIV Viral reservoir: quality rather quantity matters

This article focuses on recent virological findings by Jiang et al., that conducted a comparative investigation of the viral reservoirs of elite controllers and individuals with ART-induced functional cure. Authors…

ChelekaSeptember 21, 2020

breaking news

We need innovative tools to diagnose Coeliac disease

Coeliac disease is a complex autoimmune condition which currently affects 1% of the global population. Due to its complexity, the diagnosis of the diseases poses unique challenges and patients often…

ChelekaSeptember 18, 2020

breaking news

IUIS Webinar: Tracking SARS-CoV-2 in Ghana

In this webinar researchers from the University of Ghana discuss the analysis of SARS-CoV-2 sequences which include imported and circulating viruses at the inception of Ghana’s outbreak, and circulating viruses…

ChelekaSeptember 16, 2020

breaking news

Inclusion of non-spike proteins in SARS-CoV-2 vaccines may be important for the induction of protective T cell memory.

A recent study published in Nature Immunology shows the presence of SARS-CoV-2 specific memory T cell responses in patients recovered from COVID-19. The breadth and strength of SARS-CoV-2-specific T cell…

ChelekaSeptember 15, 2020

breaking news

CD229 CAR: New therapy for multiple myeloma

Multiple myeloma (MM) is a clonal plasma cell malignancy which causes an incurable disease. This summary discusses CD229 CAR as potential new therapy for Multiple myeloma. MM develops in bone…

ChelekaSeptember 14, 2020

breaking news

Immuno-Algeria: Drug hypersensitivity in TB/HIV endemic settings

Our final Immuno-Algeria highlight is a on a talk by Professor Jonny Peter (UCT, SA), who gave an excellent talk about drug hypersensitivity in TB/HIV endemic settings. He began his…

ChelekaSeptember 11, 2020

breaking news

SAIS/Immunopaedia Webinar on BCG & COVID-19

This webinar, co-hosted by South African Immunology Society (SAIS) and Immunoapedia featured talks by Prof Christine Benn on “BCG for COVID-19 - hope or hype?” & Prof Gerhard Walz on…

ChelekaSeptember 9, 2020

breaking news

Male and female immune responses to SARS-CoV-2 substantially differ.

A recent paper in Nature has shown some key differences in immune responses during COVID-19 between males and females. The authors found that in SARS-CoV-2 infected males, levels of proinflammatory…

ChelekaSeptember 8, 2020

breaking news

How the Regulator is Regulated: Insight into immune-related Protein holds therapeutic value

Researchers led by Professor Chiharu Nishiyama investigated the gene expression mechanism of PD-L2, a cell-surface molecule that is specifically expressed by DCs and macrophages. In DCs, PD-L2 acts as a…

ChelekaSeptember 7, 2020

breaking news

Immuno-Algeria: Non-invasive allergy biomarkers & next-gen immunotherapies

This week we shall highlight IUIS-FAIS-SAI-AAA Immuno-Algeria lectures by Professors Carsten Schmidt-Weber and Claude Lambert on non-invasive methods to diagnose and monitor allergy response, as well as a lecture by…

ChelekaSeptember 4, 2020

breaking news

Are Lung microbial products driving hyperinflammation in severe COVID-19?

A recent paper in Science used a systems biology approach to determine host immune responses to COVID-19 using an array of cellular and molecular procedures. On initial immune cell screening,…

ChelekaSeptember 3, 2020

breaking news

IUIS Webinar: COVID-19 & Immune Compromise

In this Webinar, Kathleen Sullivan discusses how COVID-19 impacts immunodeficient patients. She began her talk emphasising that majority of COVID-19 research has focused on pathogenesis, however, very limited knowledge is…

ChelekaSeptember 2, 2020

Safety and immunogenicity of the Ad26.COV2.S COVID-19 vaccine candidate.

Why do people with the Dantu blood group have a lower risk of developing malaria?

Boosting of antibody responses against the V2 and V3 region of the HIV-1 Env

SAIS/Immunopaedia COVID-19 Webinar on Severe vs mild COVID-19 immunity, and intersection between Nicotinamide pathway & COVID-19.

A mechanism for severe COVID-19 in patients with obesity and diabetes?

HIV Viral reservoir: quality rather quantity matters

We need innovative tools to diagnose Coeliac disease

IUIS Webinar: Tracking SARS-CoV-2 in Ghana

Inclusion of non-spike proteins in SARS-CoV-2 vaccines may be important for the induction of protective T cell memory.

CD229 CAR: New therapy for multiple myeloma

Immuno-Algeria: Drug hypersensitivity in TB/HIV endemic settings

SAIS/Immunopaedia Webinar on BCG & COVID-19

Male and female immune responses to SARS-CoV-2 substantially differ.

How the Regulator is Regulated: Insight into immune-related Protein holds therapeutic value

Immuno-Algeria: Non-invasive allergy biomarkers & next-gen immunotherapies

Are Lung microbial products driving hyperinflammation in severe COVID-19?

IUIS Webinar: COVID-19 & Immune Compromise

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