October 2019

IDA Highlight: Scanning the TCR repertoire to inform new TB vaccine targets

There are 4000 known M.tb antigens, current strategies exploring potential epitopes to target use IFN-Y ELISA to determine cellular responses to people infected (versus uninfected) to see if they elicit…

ChelekaOctober 31, 2019

breaking news

IDA Highlight: Possible barriers and opportunities for HIV cure

Thumbi N’dungu from African Health Research Institute (AHRI) was one of the faculty members, who presented on “Possible barriers and opportunities for HIV cure in patients who initiate treatment during…

ChelekaOctober 30, 2019

breaking news

IDA Highlight: Not all levels of malaria exposure induce the same anti-malarial immunity

We highlight Dr Yaw Bediako’s (faculty) presentation on “Performing immunological studies in human cohorts - Systems approaches to studying immunity to malaria”.

ChelekaOctober 29, 2019

The current TB vaccine pipeline (last update September 2019). Source: TuBerculosis Vaccine Intitiative (TBVI) [tbvi.eu/what-we-do/pipeline-of-vaccines/]

breaking news

IDA Highlight: Immune responses to TB vaccines

Dr Elisa Nemes from SATVI presented on the current status of TB vaccinology, where she primarily focused immunological aspects of tested vaccine strategies. Immunoprofiling of TB-vaccine induced immunity, still primarily…

ChelekaOctober 28, 2019

breaking news

IDA Highlight: CD4 T cells in HIV infection

CD4 T cells are well known as the main target for HIV infection, however, their T cell antiviral activity during His infection is not as well known. This year the…

ChelekaOctober 23, 2019

breaking news

Career Advice from IDA faculty that were once previous IDA Scholars

The 9th IDA Symposium began with a "Science and Career Advice" session presented by speakers who were once IDA as a student or Post-Doc, and are now faculty members. Highlights…

ChelekaOctober 18, 2019

Title MRI of Breast Description Color-enhancement show magnetic resonance image (MRI) of individual breast. Topics/Categories Anatomy -- Breast Test or Procedure -- Imaging Procedures Type Color, Photo Source Dr. Steven Harmes. Baylor University Medical Center, Dallas Texas (Source: WIkimedia Commons)

breaking news

Lipid profiles key step to preventing breast cancer metastasis through epithelial-mesenchymal transition

Early detection of breast cancer offers curable options, however, once metastasized the cancer cannot be cured. With higher rates of breast cancer correlated with western diet consumption...

ChelekaOctober 15, 2019

breaking news

The Vaccinology course, if you are in the vaccine-world, you shouldn´t miss it!

Since 2008 the Institut Pasteur in Paris, France has facilitated the Vaccinology Course, a course that covers all aspects of vaccines and vaccination, and allows participants from all over the…

ChelekaOctober 10, 2019

breaking news

Investigating the immunological composition of the Kidney

Researchers recently published an article in Science (Stewart et al.,) describing the immune composition of anatomical structures of the kidney, and how they differ between early life (fetus) and adulthood.…

ChelekaOctober 4, 2019

TH17 cells are functionally and metabolically heterogeneous, and are composed of a subset with stemness features but lower anabolic metabolism, and a reciprocal subset with higher metabolic activity that supports transdifferentiation into TH1 cells. These two subsets are further distinguished by selective expression of the transcription factors TCF-1 and T-bet, respectively, and discrete levels of CD27 expression. mTORC1 activation drives reprogramming of anabolic metabolism, favouring transcription that is mediated by T-bet rather than TCF-1; consequently, TH17 transdifferentiation into TH1-like TH17 cells occurs. Memory/stem-like TH17 cells can become reactivated and have the potential to undergo terminal differentiation and acquire TH1-like phenotypes. (Source Karmaus et al., 2019)

breaking news

CD27 expression identifies Th17 cells with high stemness properties

Karmaus et al., showed that during chronic autoimmunity Th17 cells are heterogenous, where Th17 cells with enriched stemness properties are CD27+TCF1hi, while IFN-γ expressing Th17 cells with high metabolic activity…

ChelekaOctober 2, 2019

IDA Highlight: Scanning the TCR repertoire to inform new TB vaccine targets

IDA Highlight: Possible barriers and opportunities for HIV cure

IDA Highlight: Not all levels of malaria exposure induce the same anti-malarial immunity

IDA Highlight: Immune responses to TB vaccines

IDA Highlight: CD4 T cells in HIV infection

Career Advice from IDA faculty that were once previous IDA Scholars

Lipid profiles key step to preventing breast cancer metastasis through epithelial-mesenchymal transition

The Vaccinology course, if you are in the vaccine-world, you shouldn´t miss it!

Investigating the immunological composition of the Kidney

CD27 expression identifies Th17 cells with high stemness properties

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