September 2019

New fungus-derived antibiotic: relief in sight for immunocompromised people

Scientists derive a new compound from eushearilide, which can potentially take on lethal fungal and bacterial infections.Infections that are treatable in healthy people can often be fatal in immunocompromised individuals…

ChelekaSeptember 27, 2019

breaking news

HIV RV144 vaccine induces better responses in SA compared to Thailand

Amazing results from the RV144 trials indicated the potential of this vaccine, thus Gray et al., 2019 designed a study (HVTN097) to determine safety and immunogenicity of the RV144 vaccine regimen in…

ChelekaSeptember 25, 2019

breaking news

Rethinking HIV remission strategies: end of the road for anti-α4β7 ?

Byrareddy et al., 2016 (HIV R4P Highlights: α4β7 antibody and ART: a novel HIV therapy) demonstrated the ability of anti-α4β7 in preventing viral rebound in the absence of ART. This promising result…

ChelekaSeptember 20, 2019

Hill et al., Graphical Abstract. Source Hill et al., JEM)

breaking news

GLA-SE promotes superior Tfh expansion than Alum

Since Tfh cells play a critical role in the generation of long-live Ab responses, targeting them using adjuvants is a potential way of improving vaccine strategies. Tfh cells are relatively understudied…

ChelekaSeptember 17, 2019

Highlights: Germline transcripts peak prior to GC formation and rapidly decline in GCs. IgM-dominated clones are found in late GCs, arguing against ongoing Ig switching CSR largely ceases upon the onset of somatic hypermutation CSR decline due to low GLT and APE1 expression is possibly orchestrated by BCL6 (Source: Roco et al., Graphical Abstract. Immunity)

breaking news

Class-switch recombination of antibodies occurs prior to germinal center formation.

It is believed that upon immunization, two important processes occur that alter the function and reactivity of antibodies (immunoglobulins, Ig) resulting in long-lasting immune protection. One process is a change…

ChelekaSeptember 13, 2019

Mascio et al. Figure 1 A-E. (Source: Mascio et al., 2019 Science)

breaking news

Can anti-α4β7 really “cure” SIV infection in ART interrupted NHPs ?

Byrareddy et al. showed that targeting α4β7 using antibodies can prevent HIV viral rebound in the absence of ART in NHPs. Researchers have attempted to replicate Byrareddy et al., findings and 3…

ChelekaSeptember 11, 2019

breaking news

New insights into the role of HPV oncoproteins and immune response in cervical cancer

Cervical cancer, one of the top 5 common cancers in women globally, is often associated with high-risk human papillomavirus (HPV) infections such as oncogenic HPV16 and HPV18.

ChelekaSeptember 6, 2019

breaking news

Did you know neutrophils can help to form gallstones?

Despite the high morbidity, the mechanism of gallstones development, specifically factors that contribute to cholesterol and calcium aggregation is not well understand. Recent research published in Immunity by Muñoz et.,…

ChelekaSeptember 4, 2019

New fungus-derived antibiotic: relief in sight for immunocompromised people

HIV RV144 vaccine induces better responses in SA compared to Thailand

Rethinking HIV remission strategies: end of the road for anti-α4β7 ?

GLA-SE promotes superior Tfh expansion than Alum

Class-switch recombination of antibodies occurs prior to germinal center formation.

Can anti-α4β7 really “cure” SIV infection in ART interrupted NHPs ?

New insights into the role of HPV oncoproteins and immune response in cervical cancer

Did you know neutrophils can help to form gallstones?

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