July 2019

Investigating the HIV viral reservoir during acute infection

CD4 TSCM and TCM cells are considered to play a major role in long-term maintenance of the viral reservoir. However, research of the viral reservoir during acute phase of HIV infection is limited.…

ChelekaJuly 29, 2019

Quantitative histocytometry was used to identify the location of CD4 T cells (blue) and p-S6+CD4 T cells (green) relative to infected cells (red) in lung sections at day 10 (B) and sites of infection at day 14 (F).

breaking news

How does BCG affect early innate immune responses?

To determine if BCG affects early kinetics of M.tb infection and lymphocyte recruitment, Delahaye et al., compared immune responses between naive- and BCG-vaccinated mice infected with M.tb. They showed that…

ChelekaJuly 24, 2019

Illustration of Human and Murine experimental plan used in Portluri et al.,. (Source: Portluri et al., 2019)

breaking news

Sex associated differences to flu vaccination: role of estradiol?

Researchers have observed sex differences influenza vaccine induced immunity, illustrated by faster seroconversion, higher titres of neutralising antibodies and lower hospitalisation rates in females compared to males. Most of these…

ChelekaJuly 19, 2019

breaking news

Propagation of α-synuclein from the gut to brain – new causation for Parkinson’s disease?

The cause of Parkinson’s Disease is unknown, with research pointing towards a complex interplay of genetic and environmental factors. New research by Kim et al., however has ...

ChelekaJuly 17, 2019

breaking news

Have you heard of Mycetoma ?

Evidence from a murine model of mycetoma suggests that IL-17 producing T cells, termed Th17 cells may play a role in mycetoma pathogenesis. IL-17 is a pro-inflammatory cytokine which can…

ChelekaJuly 15, 2019

Raulf et al., Graphical Abstract. (Source Cell Reports)

breaking news

How does plasmodial hemozoin contribute to cerebral malaria pathogenesis?

Phagocytic ingestion of hemozoin results in production of pro-inflammatory cytokines and reactive oxygen species (ROS), thus suggesting a potential mechanism of hemozoin induced immuno-pathogenesis. Rualf et al., used...

ChelekaJuly 10, 2019

Ponzetta et al., 2019. Graphical Abstract

breaking news

Are neutrophils in the tumor microenvironment friend or foe?

Neutrophils have been implicated in tumor pathology, where studies have reported a positive association between high neutrophil levels and tumor progression. Researchers from Europe (Ponzetta et al.,) aimed to determine...

ChelekaJuly 5, 2019

breaking news

Animal models to measure mucosal innate immunity: zebrafish vs mice.

The use of an inappropriate animal model that is not similar to human pathology or disease progression can slow the development of new therapeutics. Progatzky et al., aimed to compare…

ChelekaJuly 3, 2019

Investigating the HIV viral reservoir during acute infection

How does BCG affect early innate immune responses?

Sex associated differences to flu vaccination: role of estradiol?

Propagation of α-synuclein from the gut to brain – new causation for Parkinson’s disease?

Have you heard of Mycetoma ?

How does plasmodial hemozoin contribute to cerebral malaria pathogenesis?

Are neutrophils in the tumor microenvironment friend or foe?

Animal models to measure mucosal innate immunity: zebrafish vs mice.

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