How does IL-27 attenuate autoimmune neuroinflammation?
![Experimental design of EAE induction and Treg adoptive transfer. Groups (n = 5∼ 8) of Foxp3DTR mice were induced for EAE as described in Materials and Methods. At disease onset (7 d postinduction), mice were treated with 1 mg of DTx alone (filled circle). Some mice received 5 3 106 Foxp3+ iTregs together with DTx (open square). The mice were daily monitored and scored for clinical diseases and survival. (Source Kim et al., Fig 1.A)]()
Researchers are currently exploring the potential use of IL-27 as an immunotherapeutic agent. An example of this, is the experimental administration...
ChelekaFebruary 27, 2019
