September 2018

Schematic showing the position of PPE 18 (Mtb39a) in the M72 GSK vaccine. Source: Brennen. Infection and Immunity 2017.

2018: The year of hope for TB vaccines

26th September, 2018 On the eve of the UNHLMTB meeting, results from the Phase 2b M72/AS01E vaccine trial were published in the NEJM. This study represents the first TB vaccine…

ChelekaSeptember 26, 2018

breaking news

Is CD153 essential for M.tb control ?

25th September, 2018 CD4 T cells, particularly those that express IFN-γ have been shown to be essential for control of Mycobacterium tuberculosis infection in both animal models and humans. However,…

ChelekaSeptember 25, 2018

Regulation of osteoclast differentiation in Rheumatoid arthritis: Upregulation of proinflammatory cytokines activates osteoclastogenesis. Kazuo Okamoto and Hiroshi Takayanagi, 2011,Arthritis Research and Therapy.

breaking news

Omentin-1 rescues inflammation-induced osteoporosis

19th September, 2018 Recent work by Shan-Shan Rao et. al, has highlighted the potential of Omentin-1 in downregulating the activity of proinflammatory cytokines, thereby unravelling its mechanism ...

ChelekaSeptember 19, 2018

Source: WHO Global Hepatitis Report (http://www.who.int/hepatitis/publications/global-hepatitis-report2017/en/)

breaking news

New hope from chronic HBV patients: non-replicative Ad-HBV vaccine

14th September, 2018 Hepatitis B (HBV) remains a global health problem, with two billion people having serologic evidence of past or ongoing HBV infection.An estimated 257 million people, 3.5% of…

ChelekaSeptember 14, 2018

breaking news

Have you heard of analytic treatment interruption of HIV ART?

12th September One of the goals for the HIV research field is to achieve a functional cure for HIV, the elimination of detectable virus without the use of ART. Clinical…

ChelekaSeptember 12, 2018

Docking poses of R-PZQ (light red) and S-PZQ (light blue) in the human 5HT2BR. Both isomers of PZQ dock favorably within the orthosteric pocket of the 5HT2BR crystal structure (Protein Databank Code: 5TVN). The R-isomer shows a better predicted binding score by 0.6 kcal/mole partially due to a more favorable hydrogen bond with the backbone NH group of L209. Source: Chan et al., 2017

breaking news

A novel function of the antihelminthic drug Praziquantel: new strategy for combatting schistosomiasis

Interesting work by Chan and colleagues describes an unknown mechanism of action of the tetracyclic tetrahydroisoquinoline praziquantel (PZQ) the drug ...

ChelekaSeptember 7, 2018

breaking news

What is the incubation period of TB?

5th September 2018 A recent Analysis by Behr et al., “Revisiting the timetable of tuberculosis”, highlights the need for improved understanding of the timeline of TB progression and its implications…

ChelekaSeptember 5, 2018

2018: The year of hope for TB vaccines

Is CD153 essential for M.tb control ?

Omentin-1 rescues inflammation-induced osteoporosis

New hope from chronic HBV patients: non-replicative Ad-HBV vaccine

Have you heard of analytic treatment interruption of HIV ART?

A novel function of the antihelminthic drug Praziquantel: new strategy for combatting schistosomiasis

What is the incubation period of TB?

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